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1. WO1996002566 - VITRONECTIN BINDING PROTEIN

Publication Number WO/1996/002566
Publication Date 01.02.1996
International Application No. PCT/SE1995/000861
International Filing Date 14.07.1995
Chapter 2 Demand Filed 14.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/31 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
305from Micrococcaceae (F)
31from Staphylococcus (G)
C07K 14/78 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin (CIG)
G01N 33/569 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61K 39/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39Medicinal preparations containing antigens or antibodies
C07K 14/31
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
195from bacteria
305from Micrococcaceae (F)
31from Staphylococcus (G)
C07K 14/78
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
78Connective tissue peptides, e.g. collagen, elastin, laminin, fibronectin, vitronectin, cold insoluble globulin [CIG]
G01N 33/56944
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
56911Bacteria
56944Streptococcus
Applicants
  • FLOCK, Jan-Ingmar [SE/SE]; SE
  • WADSTRÖM, Torkel [SE/SE]; SE
  • LIANG, Olin [CN/SE]; SE
Inventors
  • FLOCK, Jan-Ingmar; SE
  • WADSTRÖM, Torkel; SE
  • LIANG, Olin; SE
Agents
  • NILSSON, Ingemar ; H. Albihns Patentbyrå AB P.O. Box 3137 S-103 62 Stockholm, SE
Priority Data
9402490-815.07.1994SE
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) VITRONECTIN BINDING PROTEIN
(FR) PROTEINE SE FIXANT A LA VITRONECTINE
Abstract
(EN)
The present invention concerns a new vitronectin binding protein from Streptococcus aureus. The protein is involved in the infectious process of the microorganism. The invention also concerns a method for preparation thereof and a quinquedecapeptide with the amino acid sequence AKKQRFRHRNRKGYR, that is useful for preparing the protein and blocking the protein binding site to vitronectin. Further the invention relates to an antibody against the protein, pharmaceutical compositions and a diagnostic or analytical kit comprising said protein, peptide or antibody and a vaccine. Finally, the invention concerns a method for purifying vitronectin by using the vitronectin binding protein in an affinity column.
(FR)
La présente invention concerne une nouvelle protéine se fixant à la vitronectine et provenant de Streptococcus aureus. Cette protéine intervient dans le processus d'infection par ce micro-organisme. L'invention concerne également un procédé de préparation de cette protéine et d'un pentadécapeptide qui a la séquence d'acides aminés AKKQRFRHRNRKGYR et qui est utile pour préparer la protéine et pour bloquer le site de fixation de la protéine à la vitronectine. En outre, l'invention concerne un anticorps dirigé contre la protéine, des compositions pharmaceutiques, un coffret de diagnostic ou d'analyse comprenant ladite protéine, peptide ou anticorps, ainsi qu'un vaccin. Finalement, l'invention concerne un procédé pour purifier la vitronectine en utilisant la protéine se fixant à la vitronectine, dans une colonne d'affinité.
Also published as
Latest bibliographic data on file with the International Bureau