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1. WO1996002560 - OLIGONUCLEOSIDE COMPOUNDS AND METHODS FOR INHIBITING TUMOR GROWTH, INVASION AND METASTASIS

Publication Number WO/1996/002560
Publication Date 01.02.1996
International Application No. PCT/US1995/009040
International Filing Date 18.07.1995
Chapter 2 Demand Filed 16.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C12N 9/12 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
C12N 15/11 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C12N 15/1137
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
11DNA or RNA fragments; Modified forms thereof
113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
1137against enzymes
C12N 2310/315
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
2310Structure or type of the nucleic acid
30Chemical structure
31of the backbone
315Phosphorothioates
C12N 9/1205
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9Enzymes; Proenzymes; Compositions thereof
10Transferases (2.)
12transferring phosphorus containing groups, e.g. kinases (2.7)
1205Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
Applicants
  • UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL [US/US]; 300 Bynum Hall Campus Box 4100 Chapel Hill, NC 27599-4100, US (AllExceptUS)
  • CANCE, William, G. [US/US]; US (UsOnly)
  • LIU, Edison, T. [US/US]; US (UsOnly)
  • OWENS, Lewis, V. [US/US]; US (UsOnly)
Inventors
  • CANCE, William, G.; US
  • LIU, Edison, T.; US
  • OWENS, Lewis, V.; US
Agents
  • MEIER, Paul, H. ; Lyon & Lyon First Interstate World Center Suite 4700 633 West Fifth Street Los Angeles, CA 90071-2066, US
Priority Data
08/276,84318.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) OLIGONUCLEOSIDE COMPOUNDS AND METHODS FOR INHIBITING TUMOR GROWTH, INVASION AND METASTASIS
(FR) COMPOSES OLIGONUCLEOSIDIQUES ET PROCEDES D'INHIBITION DE LA CROISSANCE, L'INVASION ET LA METASTASE TUMORALES
Abstract
(EN)
Oligonucleoside compounds useful in inhibiting expression of focal adhesion kinase protein in animals, and related methods and formulations for reducing cancer cell growth, invasion and metastasis. The compounds are selected to be complementary to a target region of a focal adhesion kinase nucleic acid sequence, preferably human FAK mRNA.
(FR)
Composés oligonucléosidiques convenant à l'inhibition de l'expression de la protéine kinase d'adhésion focale chez les animaux, procédés et préparations associés pour réduire la croissance, l'invasion et la métastase des cellules cancéreuses. Ces composés sont sélectionnés de sorte qu'ils soient complémentaires à une région cible d'une séquence d'acide nucléique de la kinase d'adhésion focale, de préférence l'ARNm de la kinase d'adhésion focale humaine.
Also published as
Latest bibliographic data on file with the International Bureau