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1. WO1996002558 - LINKED PEPTIDE NUCLEIC ACIDS

Publication Number WO/1996/002558
Publication Date 01.02.1996
International Application No. PCT/US1995/009084
International Filing Date 13.07.1995
Chapter 2 Demand Filed 14.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
C12N 15/10 2006.01
CCHEMISTRY; METALLURGY
12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09Recombinant DNA-technology
10Processes for the isolation, preparation or purification of DNA or RNA
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 31/12
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
31Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
12Antivirals
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 43/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
43Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
C07K 14/003
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
001by chemical synthesis
003Peptide-nucleic acids (PNAs)
Applicants
  • ISIS PHARMACEUTICALS, INC. [US]/[US] (AllExceptUS)
  • PERSEPTIVE BIOSYSTEMS [US]/[US] (AllExceptUS)
  • BUCHARDT, Dorte [DK]/[DK]
  • EGHOLM, Michael [DK]/[US]
  • NIELSEN, Peter [DK]/[DK]
  • DUEHOLM, Kim, L. [DK]/[DK] (UsOnly)
  • CHRISTENSEN, Leif [DK]/[DK] (UsOnly)
  • COULL, James, M. [US]/[US] (UsOnly)
  • KIELY, John [US]/[US] (UsOnly)
  • GRIFFITH, Michael [US]/[US] (UsOnly)
Inventors
  • EGHOLM, Michael
  • NIELSEN, Peter
  • DUEHOLM, Kim, L.
  • CHRISTENSEN, Leif
  • COULL, James, M.
  • KIELY, John
  • GRIFFITH, Michael
  • BUCHARDT, Ole
Agents
  • CALDWELL, John, W.
Priority Data
08/275,95115.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) LINKED PEPTIDE NUCLEIC ACIDS
(FR) ACIDES NUCLEIQUES PEPTIDIQUES LIES
Abstract
(EN)
Novel peptide nucleic acids and novel linked peptide nucleic acids, form triple stranded structures with nucleic acids. The peptide nucleic acids include ligands such as naturally occurring nucleobases attached to a peptide backbone through a suitable linker. Other nucleobases including C-pyrimidines and iso-pyrimidines can be used as the ligands in Hoogsteen strands to increase binding affinity. Two peptide nucleic acid strands are joined together with a linker to form a bis-peptide nucleic acid. The individual strands of the peptide nucleic acids in the bis compounds can be oriented either parallel or antiparallel to each other.
(FR)
De nouveaux acides nucléiques peptidiques et de nouveaux acides nucléiques peptidiques liés forment des structures à trois brins avec des acides nucléiques. Les acides nucléiques peptidiques comprennent des ligands tels que des nucléobases apparaissant naturellement, fixées à un squelette peptidique par l'intermédiaire d'un lieur approprié. D'autres nucléobases comprenant des C-pyrimidines et des iso-pyrimidines peuvent être utilisées comme ligands dans des brins de Hoogsteen pour augmenter l'affinité de liaison. Deux brins d'acide nucléique peptidique sont reliés par un lieur pour former un acide nucléique bis-peptidique. Les brins individuels des acides nucléiques peptidiques du composé bis peuvent être orientés de façon à être parallèles ou anti-parallèles.
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