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1. WO1996002554 - DINUCLEOSIDE-5',5'-PYROPHOSPHATES

Publication Number WO/1996/002554
Publication Date 01.02.1996
International Application No. PCT/EP1995/002676
International Filing Date 10.07.1995
Chapter 2 Demand Filed 22.01.1996
IPC
C07H 21/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
CPC
C07H 21/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
Applicants
  • GRUPPO LEPETIT S.P.A. [IT/IT]; Via Roberto Lepetit, 8 I-20020 Lainate, IT (AllExceptUS)
  • UNIVERSITA' DEGLI STUDI DI GENOVA [IT/IT]; Via Balbi, 5 I-16126 Genova, IT (AllExceptUS)
  • DE FLORA, Antonio [IT/IT]; IT (UsOnly)
  • BENATTI, Umberto [IT/IT]; IT (UsOnly)
  • GIOVINE, Marco [IT/IT]; IT (UsOnly)
Inventors
  • DE FLORA, Antonio; IT
  • BENATTI, Umberto; IT
  • GIOVINE, Marco; IT
Agents
  • SGARBI, Renato; Gruppo Lepetit S.p.A. Patent & Trademark Dept. Via R. Lepetit, 34 I-21040 Gerenzano, IT
Priority Data
94202059.515.07.1994EP
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) DINUCLEOSIDE-5',5'-PYROPHOSPHATES
(FR) 5',5'-PYROPHOSPHATES DE DINUCLEOSIDES
Abstract
(EN)
5',5'-Pyrophosphates of non-naturally occurring nucleosides selected from thymine-3'-azido-2',3'-dideoxy-D-riboside, 5-fluorouracil-2'-deoxy-D-riboside, uracil-3'-azido-2',3'-dideoxy-D-riboside, guanine-2',3'-dideoxy-D-riboside, hypoxanthine-2',3'-dideoxy-D-riboside, cytosine-2',3'-dideoxy-D-riboside, and adenine-2',3'-dideoxy-D-riboside, are described as well as their manufacture and use as therapeutical agents against tumors and retroviral infections including HIV infections. The compounds may be administered as the active ingredients of pharmaceutical compositions or as pro-drugs encapsulated into biological carriers, e.g., transformed erythrocytes, for targeting to specific cell population responsible of the development of the pathological disorders.
(FR)
L'invention concerne des 5',5'-pyrophosphates de nucléosides d'origine non naturelle, sélectionnés parmi le thymine-3'-azido-2',3'-didésoxy-D-riboside, le 5-fluorouracil-2'-désoxy-D-riboside, l'uracil-3'-azido-2',3'-didésoxy-D-riboside, le guanine-2',3'-didésoxy-D-riboside, l'hypoxanthine-2',3'-didésoxy-D-riboside, le cytosine-2',3'-didésoxy-D-riboside et l'adénine-2',3'-didésoxy-D-riboside. L'invention concerne également leur procédé de production et leur utilisation en tant qu'agents thérapeutiques contre les tumeurs et les infections rétrovirales y compris les infections au VIH. Ces composés peuvent être administrés en tant que principe actif de compositions pharmaceutiques ou sous forme de promédicaments encapsulés dans des excipients biologiques, par ex. des érythrocytes transformés, afin de lutter contre des populations de cellules cibles responsables du développement de troubles pathologiques.
Also published as
FI970081
KR1019970700225
NO19965483
NZ290127
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