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1. WO1996002553 - AMINO PURINE-$g(b)-D-RIBOFURANURONAMIDE DERIVATIVES

Publication Number WO/1996/002553
Publication Date 01.02.1996
International Application No. PCT/EP1995/002837
International Filing Date 14.07.1995
Chapter 2 Demand Filed 15.01.1996
IPC
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
16
Purine radicals
C07H 19/16 (2006.01)
CPC
C07H 19/16
Applicants
  • GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
  • AYRES, Diana, Sally [GB/GB]; GB (UsOnly)
  • GREGSON, Michael [GB/GB]; GB (UsOnly)
  • EWAN, George, Blanch [GB/GB]; GB (UsOnly)
  • KEELING, Suzanne, Elaine [GB/GB]; GB (UsOnly)
  • BELL, Richard [GB/GB]; GB (UsOnly)
Inventors
  • GREGSON, Michael; GB
  • EWAN, George, Blanch; GB
  • KEELING, Suzanne, Elaine; GB
  • BELL, Richard; GB
  • AYRES, Barry, Edward; null
Agents
  • DAWSON, Hugh, B. ; Glaxo Wellcome plc Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB
Priority Data
9414193.414.07.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) AMINO PURINE-$g(b)-D-RIBOFURANURONAMIDE DERIVATIVES
(FR) DERIVES AMINO PURINE-$g(b)-D-RIBOFURANURONAMIDE
Abstract
(EN)
Amino purine-$g(b)-D-ribofuranuronamide derivatives are described having general formula (I) and salts and solvates thereof, wherein: R1 is hydrogen, C3-8cycloaklyl or C1-6alkyl; A represents O, S, SO, SO2, a saturated hydrocarbon moiety having from 1 to 4 carbon atoms or an unsaturated hydrocarbon moiety having from 2 to 4 carbon atoms; R2 is C3-8cycloalkyl, C3-8cycloalkyl C1-6alkyl, Alk1Y, -(CHR5)m (Alk2)nZ or appropriately substituted C3-8cycloalkyl, C3-8cycloalkylC1-6alkyl, pyrrolidin-3-yl, 2-oxopyrrolidin-4-yl, 2-oxopyrrolidin-5-yl, piperidin-3-yl or piperidin-4-yl, and Q is oxygen or sulphur with the proviso that when A represents O, S, SO or SO2, Alk1 represents a C2-6alkylene group. Compounds of formula (I) and their salts and solvates have use in medicine as anti-inflammatory agents, particularly in the treatment of patients with inflammatory conditions who are susceptible to leukocyte-induced tissue damage.
(FR)
L'invention concerne des dérivés amino purine-$g(b)-D-ribofuranuronamide de formule générale (I) ainsi que leurs sels et solvates. Dans cette formule, R1 est hydrogène, cycloalkyleC3-8 ou alkyleC1-6; A représente O, S, SO, SO2, un fragment hydrocarbure saturé possédant de 1 à 4 atomes de carbone ou bien un fragment hydrocarbure insaturé possédant de 2 à 4 atomes de carbone; R2 est cycloalkyleC3-8, cycloalkyleC3-8 alkyleC1-6, Alk1Y, -(CHR5)m (Alk2)nZ ou bien cycloalkyleC3-8, cycloalkyleC3-8 alkyleC1-16 à substitution appropriée, pyrrolidin-3-yl, 2-oxopyrrolidin-4-yl, 2-oxopyrrolidin-5-yl, piperidin-3-yl ou piperidin-4-yl, et Q est oxygène ou soufre à condition que lorsque A représente O, S, SO ou bien SO2, Alk1 représente un groupe alkylèneC2-6. Ces composés de formule (I) ainsi que leurs sels et solvates s'utilisent en médecine comme agents anti-inflammatoires, notamment dans le traitement de patients atteints de manifestations inflammatoires, qui sont sujets à des lésions tissulaires à induction leucocytaire.
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