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1. WO1996002547 - DIOXO-THIOPYRANO-PYRIDINE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS MEDICAMENTS

Publication Number WO/1996/002547
Publication Date 01.02.1996
International Application No. PCT/EP1995/002546
International Filing Date 30.06.1995
Chapter 2 Demand Filed 12.02.1996
IPC
C07D 495/04 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
CPC
C07D 495/04
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
495Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
02in which the condensed system contains two hetero rings
04Ortho-condensed systems
Applicants
  • BAYER AKTIENGESELLSCHAFT [DE/DE]; D-51368 Leverkusen, DE (AllExceptUS)
  • URBAHNS, Klaus [DE/DE]; DE (UsOnly)
  • HEINE, Hans-Georg [DE/DE]; DE (UsOnly)
  • JUNGE, Bodo [DE/DE]; DE (UsOnly)
  • SCHOHE-LOOP, Rudolf [DE/DE]; DE (UsOnly)
  • SOMMERMEYER, Henning [DE/DE]; DE (UsOnly)
  • GLASER, Thomas [DE/DE]; DE (UsOnly)
  • WITTKA, Reilinde [DE/DE]; DE (UsOnly)
  • DE VRY, Jean-Marie-Viktor [BE/DE]; DE (UsOnly)
Inventors
  • URBAHNS, Klaus; DE
  • HEINE, Hans-Georg; DE
  • JUNGE, Bodo; DE
  • SCHOHE-LOOP, Rudolf; DE
  • SOMMERMEYER, Henning; DE
  • GLASER, Thomas; DE
  • WITTKA, Reilinde; DE
  • DE VRY, Jean-Marie-Viktor; DE
Common Representative
  • BAYER AKTIENGESELLSCHAFT; D-51368 Leverkusen, DE
Priority Data
P 44 24 678.113.07.1994DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) DIOXO-THIOPYRANO-PYRIDIN-CARBONSÄURE-DERIVATE UND IHRE VERWENDUNG ALS ARZNEIMITTEL
(EN) DIOXO-THIOPYRANO-PYRIDINE CARBOXYLIC ACID DERIVATIVES AND THEIR USE AS MEDICAMENTS
(FR) DERIVES D'ACIDE CARBOXYLIQUE DE DIOXO-THIOPYRANO-PYRIDINE ET LEUR UTILISATION COMME MEDICAMENTS
Abstract
(DE)
Dioxo-thiopyrano-pyridin-carbonsäure-derivate der Formel (I) werden hergestellt, indem man entsprechende Aldehyde mit Aminocrotonsäureester und Tetrahydrothiopyran-3-on-1,1-dioxid umsetzt und die so erhaltenen Produkte oxidiert. Die erfindungsgemässen Stoffe können als Wirkstoffe in Arzneimittel eingesetzt werden. Sie sind selektive Modulatoren der calciumabhängigen Kalium-Kanäle mit grosser Leitfähigkeit.
(EN)
Dioxo-thiopyrano-pyridine carboxylic acid derivatives of formula (I) are produced by reacting corresponding aldehydes with aminocrotonic acid ester and tetrahydrothiopyrane-3-one-1,1 dioxyde and oxidising the products thus obtained. The substances of the invention can be used as active agents in medicaments. They are selective modulators of the calcium-dependent potassium channels of high conductivity.
(FR)
On obtient des dérivés d'acide carboxylique de dioxo-thiopyrano-pyridine de la formule (I) par réaction d'aldéhydes correspondants avec des esters d'acide aminocrotonique et du tétrahydrothiopyranne-3-one-1,1-dioxyde, et par oxydation des produits obtenus. Les substances obtenues selon l'invention peuvent s'utiliser comme principes actifs de médicaments. Ces substances constituent des modulateurs sélectifs des canaux à potassium calciodépendants à grande conductibilité.
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