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1. WO1996002543 - 2,3-DIHYDROXY CYCLOPENTANE DERIVATIVES OF PURINES

Publication Number WO/1996/002543
Publication Date 01.02.1996
International Application No. PCT/EP1995/002705
International Filing Date 12.07.1995
Chapter 2 Demand Filed 15.01.1996
IPC
C07D 473/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
CPC
C07D 473/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
473Heterocyclic compounds containing purine ring systems
Applicants
  • GLAXO GROUP LIMITED [GB/GB]; Glaxo House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
  • AYRES, Diana, Sally [GB/GB]; GB (UsOnly)
  • GREGSON, Michael [GB/GB]; GB (UsOnly)
  • EWAN, George, Blanch [GB/GB]; GB (UsOnly)
  • CHANDLER, Malcolm [GB/GB]; GB (UsOnly)
Inventors
  • GREGSON, Michael; GB
  • EWAN, George, Blanch; GB
  • CHANDLER, Malcolm; GB
  • AYRES, Barry, Edward; null
Agents
  • DAWSON, Hugh, B. ; Glaxo Wellcome plc Glaxo House Berkeley Avenue Greenford Middlesex UB6 0NN, GB
Priority Data
9414208.014.07.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 2,3-DIHYDROXY CYCLOPENTANE DERIVATIVES OF PURINES
(FR) DERIVES 2,3-DIHYDROXYCYCLOPENTANE DE PURINES
Abstract
(EN)
2,3-dihydroxy cyclopentane derivatives are described having general formula (I) and salts and solvates thereof, wherein: R1 is hydrogen, C3-8cycloalkyl or C1-6alkyl; R2 is C3-8 cycloalkyl, C3-8cycloalkylC1-6alkyl, Alk1Y, -(CHR5)m(Alk2)nZ or appropriately substituted C3-8cycloalkyl, C3-8cycloalkylC1-6alkyl, pyrrolidin-3-yl, 2-oxopyrrolidin-4-yl, 2-oxopyrrolidin-5-yl, piperidin-3-yl or piperidin-4-yl, and Q is oxygen or sulphur. Compounds of formula (I) and their salts and solvates have use in medicine as anti-inflammatory agents, particularly in the treatment of patients with inflammatory conditions who are susceptible to leukocyte-induced tissue damage.
(FR)
Des dérivés de 2,3-dihydroxycyclopentane ont la formule générale (I), dans laquelle R1 représente hydrogène, cycloalcoyle C3-8 ou alcoyle C1-6; R2 représente cycloalcoyle C3-8, alcoyle C1-6 de cycloalcoyle C3-8; Alk1Y, -(CHR5)m(Alk2)nZ ou cycloalcoyle C3-8, alcoyle C1-6 de cycloalcoyle C3-8, pyrrolidin-3-yle, 2-oxopyrrolidin-4-yle, 2-oxopyrrolidin-5-yle, pipéridin-3-yle ou pipéridin-4-yle substitués de manière appropriée, et Q représente oxygène ou soufre. Les composés ayant la formule (I), ainsi que leurs sels et solvates, sont utiles en médecine comme agents anti-inflammatoires, notamment pour traiter des patients souffrant d'états inflammatoires et susceptibles de présenter des lésions tissulaires induites par des leucocytes.
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