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1. WO1996002530 - PIPERIDINES AND HEXAHYDRO-1H-AZEPINES SPIRO SUBSTITUTED AT THE 4-POSITION PROMOTE RELEASE OF GROWTH HORMONE

Publication Number WO/1996/002530
Publication Date 01.02.1996
International Application No. PCT/US1995/008854
International Filing Date 17.07.1995
Chapter 2 Demand Filed 14.02.1996
IPC
C07D 471/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
CPC
C07D 471/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
471Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
02in which the condensed system contains two hetero rings
10Spiro-condensed systems
Applicants
  • MERCK & CO., INC. [US/US]; 126 East Lincoln Avenue Rahway, NJ 07065, US (AllExceptUS)
  • GUO, Liangquin [CN/US]; US (UsOnly)
  • PATCHETT, Arthur, A. [US/US]; US (UsOnly)
  • YANG, Lihu [CN/US]; US (UsOnly)
Inventors
  • GUO, Liangquin; US
  • PATCHETT, Arthur, A.; US
  • YANG, Lihu; US
Common Representative
  • MERCK & CO., INC.; 126 East Lincoln Avenue Rahway, NJ 07065, US
Priority Data
277,81020.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PIPERIDINES AND HEXAHYDRO-1H-AZEPINES SPIRO SUBSTITUTED AT THE 4-POSITION PROMOTE RELEASE OF GROWTH HORMONE
(FR) PIPERIDINES ET HEXAHYDRO-1H-AZEPINES SPIRO SUBSTITUEES EN POSITION 4 FAVORISANT LA LIBERATION DE L'HORMONE DE CROISSANCE
Abstract
(EN)
The present invention is directed to di- and tri-substituted piperidines, pyrrolidines and hexahydro-1H-azepines which promote the release of growth hormone in humans and animals. This property can be utilized to promote the growth of food animals to render the production of edible meat products more efficient, and in humans, to treat physiological or medical conditions characterized by a deficiency in growth hormone secretion, such as short stature in growth hormone deficient children, and to treat medical conditions which are improved by the anabolic effects of growth hormone. Growth hormone releasing compositions containing such di- and tri-substituted piperidines and pyrrolidines as the active ingredient thereof are also disclosed.
(FR)
L'invention concerne des pipéridines, des pyrrolidines et des héxahydro-1H-azépines di- et trisubstituées qui favorisent la libération de l'hormone de croissance chez l'homme et chez l'animal. Cette propriété peut être utilisée pour promouvoir la croissance d'animaux de boucherie pour augmenter le rendement de la production de viande comestible. Chez l'homme, elle permet de traiter des conditions physiologiques ou médicales, caractérisées par un trouble de la sécrétion d'hormone de croissance, tel que l'insuffisance staturale chez l'enfant souffrant d'une carence en hormone de croissance. Elle peut également traiter des conditions médicales qui sont améliorées par les effets anaboliques de l'hormone de croissance. L'invention traite également de compositions de libération d'hormone de croissance contenant ces pipéridines et des pyrrolidines di- et trisubstituées comme éléments actifs.
Also published as
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