Processing

Please wait...

Settings

Settings

1. WO1996002529 - THIOPHENEACETIC ACID DERIVATIVE

Publication Number WO/1996/002529
Publication Date 01.02.1996
International Application No. PCT/JP1995/001393
International Filing Date 12.07.1995
Chapter 2 Demand Filed 14.12.1995
IPC
C07D 333/24 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
333Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02not condensed with other rings
04not substituted on the ring sulfur atom
06with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
CPC
C07D 333/24
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
333Heterocyclic compounds containing five-membered rings having one sulfur atom as the only ring hetero atom
02not condensed with other rings
04not substituted on the ring sulfur
06with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to the ring carbon atoms
24Radicals substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
Applicants
  • TAISHO PHARMACEUTICAL CO., LTD. [JP/JP]; 24-1, Takata 3-chome Toshima-ku Tokyo 171, JP (AllExceptUS)
  • TOMISAWA, Kazuyuki [JP/JP]; JP (UsOnly)
  • HASEGAWA, Masahiro [JP/JP]; JP (UsOnly)
  • MITSUKUCHI, Morihiro [JP/JP]; JP (UsOnly)
  • HATAYAMA, Katsuo [JP/JP]; JP (UsOnly)
Inventors
  • TOMISAWA, Kazuyuki; JP
  • HASEGAWA, Masahiro; JP
  • MITSUKUCHI, Morihiro; JP
  • HATAYAMA, Katsuo; JP
Agents
  • ASAMURA, Kiyoshi ; Room 331, New Ohtemachi Building 2-1, Ohtemachi 2-chome Chiyoda-ku Tokyo 100, JP
Priority Data
6/16121213.07.1994JP
Publication Language Japanese (JA)
Filing Language Japanese (JA)
Designated States
Title
(EN) THIOPHENEACETIC ACID DERIVATIVE
(FR) DERIVE DE L'ACIDE THIOPHENE ACETIQUE
Abstract
(EN)
A thiopheneacetic acid derivative represented by general formula (I) and a salt thereof, each having an inflammatory cytokine production inhibitor effect and an antiphlogistic and analgesic effect and being efficacious in treating autoimmune diseases such as rheumatoid arthritis, wherein X represents hydrogen, halogen, lower alkyl, C5-C7 cycloalkyl or lower alkoxy; and R represents hydrogen or lower alkyl.
(FR)
L'invention concerne un dérivé de l'acide thiophène acétique représenté par la formule générale (I) et un sel de celui-ci, ayant des propriétés inhibitrices sur la production de cytokines inflammatoires, des propriétés antiphlogistiques et analgésiques et efficace pour traiter les maladies auto-immunes telles que la polyarthrite rhumatoïde. Dans la formule (I), X représente un hydrogène, un halogène, un alkyle inférieur, un C5-C7 cycloalkyle ou un alcoxy inférieur et R représente un hydrogène ou un alkyle inférieur.
Also published as
Latest bibliographic data on file with the International Bureau