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1. WO1996002520 - TRIAZOLE COMPOUNDS AND THEIR USE AS DOPAMINE-D¿3?-LIGANDS

Publication Number WO/1996/002520
Publication Date 01.02.1996
International Application No. PCT/EP1995/002781
International Filing Date 14.07.1995
Chapter 2 Demand Filed 02.02.1996
IPC
C07D 249/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
12Oxygen or sulfur atoms
C07D 403/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61P 1/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
08for nausea, cinetosis or vertigo; Antiemetics
C07D 249/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
249Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
02not condensed with other rings
081,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
10with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
12Oxygen or sulfur atoms
C07D 403/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
403Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • BASF AKTIENGESELLSCHAFT [DE/DE]; D-67056 Ludwigshafen, DE (AllExceptUS)
  • HELLENDAHL, Beate [DE/DE]; DE (UsOnly)
  • LANSKY, Annegret [DE/DE]; DE (UsOnly)
  • MUNSCHAUER, Rainer [DE/US]; US (UsOnly)
  • BIALOJAN, Siegfried [DE/DE]; DE (UsOnly)
  • UNGER, Liliane [DE/DE]; DE (UsOnly)
  • TESCHENDORF, Hans-Jürgen [DE/DE]; DE (UsOnly)
  • WICKE, Karsten [DE/DE]; DE (UsOnly)
  • DRESCHER, Karla [DE/DE]; DE (UsOnly)
Inventors
  • HELLENDAHL, Beate; DE
  • LANSKY, Annegret; DE
  • MUNSCHAUER, Rainer; US
  • BIALOJAN, Siegfried; DE
  • UNGER, Liliane; DE
  • TESCHENDORF, Hans-Jürgen; DE
  • WICKE, Karsten; DE
  • DRESCHER, Karla; DE
Agents
  • KINZEBACH, Werner ; Reitstötter, Kinzebach & Partner Postfach 86 06 49 D-81633 München, DE
Priority Data
P 44 25 144.015.07.1994DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) TRIAZOLVERBINDUNGEN UND DEREN VERWENDUNG ALS DOPAMIN-D3-LIGANDEN
(EN) TRIAZOLE COMPOUNDS AND THEIR USE AS DOPAMINE-D3-LIGANDS
(FR) COMPOSES TRIAZOLE ET LEUR UTILISATION COMME LIGANDS DE LA DOPAMINE-D3
Abstract
(DE)
Die vorliegende Erfindung betrifft Triazolverbindungen der Formel (I), worin R1 und R2 für H oder verschiedene Substituenten bedeuten, A für eine zweiwertige Gruppe steht, B für einen Rest der Formel (a), (b) oder (c) steht und Ar für gegebenenfalls substituiertes Phenyl, Pyridyl, Pyrimidyl oder Triazinyl steht. Die erfindungsgemäßen Verbindungen besitzen eine hohe Affinität zum Dopamin-D3-Rezeptor und sind daher zur Behandlung von Erkrankungen brauchbar, die auf Dopamin-D3-Liganden ansprechen.
(EN)
The present invention relates to triazole compounds of formula (I) in which R1, R2 stand for H or different substituents, A stands for a bivalent group, B stands for a rest of the formula (a), (b) or (c) and Ar stands for optionally substituted phenyl, pyridyl, pyrimidyl or triazinyl. The compounds of the invention have a high affinity for the dopamine-D3-receptor and are therefore usable for the treatment of diseases responding to dopamine-D3-ligands.
(FR)
L'invention concerne des composés triazole de la formule (I) dans laquelle R1 et R2 désignent H ou différents substituants, A désigne un groupe bivalent, B désigne un reste de la formule (a), (b) ou (c) et Ar désigne phényle, pyridyle, pyrimidyle ou triazinyle éventuellement substitué. Ces composés présentent une grande affinité à l'égard du récepteur de la dopamine-D3 et s'utilisent par conséquent dans le traitement d'affections réagissant à des ligands de la dopamine-D3.
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