Processing

Please wait...

PATENTSCOPE will be unavailable a few hours for maintenance reason on Sunday 05.04.2020 at 10:00 AM CEST
Settings

Settings

1. WO1996002519 - SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE

Publication Number WO/1996/002519
Publication Date 01.02.1996
International Application No. PCT/EP1995/002784
International Filing Date 14.07.1995
Chapter 2 Demand Filed 18.01.1996
IPC
A61K 31/506 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
C07D 239/38 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32One oxygen, sulfur or nitrogen atom
38One sulfur atom
C07D 239/46 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
C07D 239/56 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
56One oxygen atom and one sulfur atom
C07D 239/60 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
60Three or more oxygen or sulfur atoms
CPC
A61K 31/506
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
505Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
506not condensed and containing further heterocyclic rings
C07D 239/38
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
32One oxygen, sulfur or nitrogen atom
38One sulfur atom
C07D 239/47
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
47One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
C07D 239/56
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
56One oxygen atom and one sulfur atom
C07D 239/60
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
239Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
02not condensed with other rings
24having three or more double bonds between ring members or between ring members and non-ring members
28with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
46Two or more oxygen, sulfur or nitrogen atoms
60Three or more oxygen or sulfur atoms
Applicants
  • BASF AKTIENGESELLSCHAFT [DE/DE]; D-67056 Ludwigshafen, DE (AllExceptUS)
  • HELLENDAHL, Beate [DE/DE]; DE (UsOnly)
  • LANSKY, Annegret [DE/DE]; DE (UsOnly)
  • MUNSCHAUER, Rainer [DE/US]; US (UsOnly)
  • BIALOJAN, Siegfried [DE/DE]; DE (UsOnly)
  • UNGER, Liliane [DE/DE]; DE (UsOnly)
  • TESCHENDORF, Hans-Jürgen [DE/DE]; DE (UsOnly)
  • WICKE, Karsten [DE/DE]; DE (UsOnly)
  • DRESCHER, Karla [DE/DE]; DE (UsOnly)
Inventors
  • HELLENDAHL, Beate; DE
  • LANSKY, Annegret; DE
  • MUNSCHAUER, Rainer; US
  • BIALOJAN, Siegfried; DE
  • UNGER, Liliane; DE
  • TESCHENDORF, Hans-Jürgen; DE
  • WICKE, Karsten; DE
  • DRESCHER, Karla; DE
Agents
  • KINZEBACH, Werner ; Reitstötter, Kinzebach & Partner Postfach 86 06 49 D-81633 München, DE
Priority Data
P 44 25 143.215.07.1994DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) SUBSTITUIERTE PYRIMIDINVERBINDUNGEN UND DEREN VERWENDUNG
(EN) SUBSTITUTED PYRIMIDINE COMPOUNDS AND THEIR USE
(FR) COMPOSES SUBSTITUES DE PYRIMIDINE ET LEUR UTILISATION
Abstract
(DE)
Die vorliegende Erfindung betrifft die Verwendung von Pyrimidinverbindungen der Formel (I), worin R1, R2, R3, A, B und Ar die in der Beschreibung angegebenen Bedeutungen besitzen. Die erfindungsgemäßen Verbindungen besitzen eine hohe Affinität zum Dopamin-D3-Rezeptor und sind daher zur Behandlung von Erkrankungen brauchbar, die auf Dopamin-D3-Liganden ansprechen.
(EN)
The use is disclosed of pyrimidine compounds having the formula (I), in which R1, R2, R3, A, B and Ar have the meanings given in the description. These compounds have a high affinity for the dopamine D3 receptor and are therefore useful for treating diseases that respond to dopamine D3 ligands.
(FR)
L'invention concerne l'utilisation de composés de pyrimidine ayant la formule (I), dans laquelle R1, R2, R3, A, B et Ar ont la notation donnée dans la description. Ces composés ont une affinité élevée pour le récepteur de la dopamine D3 et sont par conséquent utiles pour traiter des maladies réagissant aux ligands de la dopamine D3.
Also published as
CZPV1997-123
FI970150
NO19970162
NZ290389
Other related publications
Latest bibliographic data on file with the International Bureau