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1. WO1996002514 - UREA AND CARBAMIC ACID DERIVATIVES, DRUGS CONTAINING THESE COMPOUNDS, AND PROCESS FOR THEIR PREPARATION

Publication Number WO/1996/002514
Publication Date 01.02.1996
International Application No. PCT/EP1995/002669
International Filing Date 10.07.1995
Chapter 2 Demand Filed 20.10.1995
IPC
C07C 275/42 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
275Derivatives of urea, i.e. compounds containing any of the groups the nitrogen atoms not being part of nitro or nitroso groups
28having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
42being further substituted by carboxyl groups
C07C 307/10 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
307Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
04Diamides of sulfuric acids
10having nitrogen atoms of the sulfamide groups bound to carbon atoms of six-membered aromatic rings
C07D 211/26 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
26with hydrocarbon radicals, substituted by nitrogen atoms
C07D 223/16 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
223Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
14condensed with carbocyclic rings or ring systems
16Benzazepines; Hydrogenated benzazepines
CPC
C07C 2601/14
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2601Systems containing only non-condensed rings
12with a six-membered ring
14The ring being saturated
C07C 275/42
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
275Derivatives of urea, i.e. compounds containing any of the groups , the nitrogen atoms not being part of nitro or nitroso groups
28having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
42being further substituted by carboxyl groups
C07C 307/10
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
307Amides of sulfuric acids, i.e. compounds having singly-bound oxygen atoms of sulfate groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
04Diamides of sulfuric acids
10having nitrogen atoms of the sulfamide groups bound to carbon atoms of six-membered aromatic rings
C07D 211/26
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
211Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
04with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
06having no double bonds between ring members or between ring members and non-ring members
08with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
18with substituted hydrocarbon radicals attached to ring carbon atoms
26with hydrocarbon radicals, substituted by nitrogen atoms
C07D 223/16
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
223Heterocyclic compounds containing seven-membered rings having one nitrogen atom as the only ring hetero atom
14condensed with carbocyclic rings or ring systems
16Benzazepines; Hydrogenated benzazepines
Applicants
  • DR. KARL THOMAE GMBH [DE/DE]; Birkendorferstrasse 65 D-88397 Biberach/Riss, DE (AllExceptUS)
  • HIMMELSBACH, Frank [DE/DE]; DE (UsOnly)
  • AUSTEL, Volkhard [DE/DE]; DE (UsOnly)
  • PIEPER, Helmut [DE/DE]; DE (UsOnly)
  • LINZ, Günter [DE/DE]; DE (UsOnly)
  • WEISENBERGER, Johannes [DE/DE]; DE (UsOnly)
  • GUTH, Brian [US/DE]; DE (UsOnly)
Inventors
  • HIMMELSBACH, Frank; DE
  • AUSTEL, Volkhard; DE
  • PIEPER, Helmut; DE
  • LINZ, Günter; DE
  • WEISENBERGER, Johannes; DE
  • GUTH, Brian; DE
Priority Data
P 44 24 974.815.07.1994DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) HARNSTOFF- UND CARBAMINSÄUREDERIVATE, DIESE VERBINDUNGEN ENTHALTENDE ARZNEIMITTEL UND VERFAHREN ZU IHRER HERSTELLUNG
(EN) UREA AND CARBAMIC ACID DERIVATIVES, DRUGS CONTAINING THESE COMPOUNDS, AND PROCESS FOR THEIR PREPARATION
(FR) DERIVES DE L'UREE ET DE L'ACIDE CARBAMIQUE, MEDICAMENTS RENFERMANT CES COMPOSES ET LEUR PROCEDE DE FABRICATION
Abstract
(DE)
Die Erfindung betrifft Harnstoff- und Carbaminsäurederivate der allgemeinen Formel (I) (R1NR2)-A-R3, in der A und R1 bis R3 wie im Anspruch 1 definiert sind, deren Tautomere, deren Stereoisomere einschließlich deren Gemischen und deren Salzen, insbesondere deren physiologisch verträglichen Salzen mit anorganischen oder organischen Säuren oder Basen, welche wertvolle pharmakologische Eigenschaften aufweisen, vorzugsweise aggregationshemmende Wirkungen, diese Verbindungen enthaltende Arzneimittel, deren Verwendung und Verfahren zu ihrer Herstellung.
(EN)
The invention concerns urea and carbamic acid derivatives of the general formula (R1NR2)-A-R3 (I), in which A and R1 to R3 are defined as in claim 1. The invention further concerns their tautomers and stereoisomers including their mixtures and salts, in particular their physiologically compatible salts with inorganic or organic acids or bases which have valuable pharmacological properties, preferably aggregation-inhibiting effects. Finally, the invention concerns drugs containing these compounds, their use and a process for their preparation.
(FR)
L'invention concerne des dérivés de l'urée et de l'acice carbamique, de formule générale (I): (R1NR2)-A-R3, dans laquelle A et R1, R2 et R3 sont tels que définis dans la revendication 1, ainsi que leurs tautomères, leur stéréoisomères, y compris leurs mélanges et leurs sels, en particulier leurs sels physiologiquement compatibles avec des acides ou des bases inorganiques ou organiques, présentant de précieuses propriétés pharmacologiques, de préférence des effets inhibiteurs d'agrégation. L'invention concerne également des médicaments renfermant ces composés, leur utilisation et leur procédé de fabrication.
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