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1. (WO1996002502) PREPARATION OF BENZINDOLE COMPOUNDS FROM NAPHTHALENE COMPOUNDS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1996/002502    International Application No.:    PCT/US1995/008958
Publication Date: 01.02.1996 International Filing Date: 18.07.1995
Chapter 2 Demand Filed:    16.02.1996    
IPC:
C07C 255/58 (2006.01), C07D 209/90 (2006.01)
Applicants: AGOURON PHARMACEUTICALS, INC. [US/US]; 10350 North Torrey Pines Road, La Jolla, CA 92037 (US)
Inventors: VARNEY, Michael, D.; (US).
PALMER, Cindy, L.; (US).
DEAL, Judy, G.; (US)
Agent: GARRETT, Arthur, S.; Finnegan, Henderson, Farabow, Garrett & Dunner, 1300 I Street, N.W., Washington, DC 20005-3315 (US)
Priority Data:
08/276,929 19.07.1994 US
Title (EN) PREPARATION OF BENZINDOLE COMPOUNDS FROM NAPHTHALENE COMPOUNDS
(FR) PREPARATION DE COMPOSES DE BENZINDOLE A PARTIR DE COMPOSES DE NAPHTALENE
Abstract: front page image
(EN)The invention relates to a process for preparing a substituted 2-amino-benz[cd]indole of formula (I). The nitro group of a substituted 1-nitro-8-cyano-naphthalene compound is reduced to an amine group to form a substituted 1-amino-8-cyano-naphthalene compound, which is cyclized to form the substituted 2-amino-benz[cd]indole. The reduction and cyclization may be effected in a one-pot procedure using a reducing agent such as stannous chloride, which generates an acid that cyclizes the reduction product. The syntheses of the 1-nitro-8-cyano-naphthalene compound and its precursors are also described.
(FR)L'invention concerne un procédé de préparation d'un 2-amino-benz[cd]indole substitué de formule (I). On réduit le groupe nitro d'un composé 1-nitro-8-cyano-naphtalène en groupe amine pour former un composé 1-amino-8-cyano-naphtalène substitué que l'on cyclise pour former le 2-amino-benz[cd]indole substitué. La réduction et la cyclisation peuvent s'effectuer selon une technique en un seul pot au moyen d'un agent de réduction tel que le chlorure stanneux qui génère un acide cyclisant le produit de réduction. Les synthèses du composé 1-nitro-8-cyano-naphtalène et de ses précurseurs sont également décrites.
Designated States: AM, AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, EE, ES, FI, GB, GE, HU, IS, JP, KE, KG, KP, KR, KZ, LK, LR, LT, LU, LV, MD, MG, MN, MW, MX, NO, NZ, PL, PT, RO, RU, SD, SE, SG, SI, SK, TJ, TM, TT, UA, UG, UZ, VN.
African Regional Intellectual Property Organization (KE, MW, SD, SZ, UG)
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)