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1. WO1996002494 - BENZOCYCLOALKYLAMINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS

Publication Number WO/1996/002494
Publication Date 01.02.1996
International Application No. PCT/EP1995/002695
International Filing Date 10.07.1995
Chapter 2 Demand Filed 20.01.1996
IPC
C07C 211/41 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
211Compounds containing amino groups bound to a carbon skeleton
33having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
39of an unsaturated carbon skeleton
41containing condensed ring systems
C07C 217/52 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
52having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
CPC
C07C 211/41
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
211Compounds containing amino groups bound to a carbon skeleton
33having amino groups bound to carbon atoms of rings other than six-membered aromatic rings
39of an unsaturated carbon skeleton
41containing condensed ring systems
C07C 217/52
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
217Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
52having etherified hydroxy groups or amino groups bound to carbon atoms of rings other than six-membered aromatic rings of the same carbon skeleton
C07C 2602/08
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
2602Systems containing two condensed rings
02the rings having only two atoms in common
04One of the condensed rings being a six-membered aromatic ring
08the other ring being five-membered, e.g. indane
Applicants
  • SMITHKLINE BEECHAM PLC [GB/GB]; New Horizons Court Brentford Middlesex TW8 9EP, GB (AllExceptUS)
  • ORLEK, Barry, Sidney [GB/GB]; GB (UsOnly)
  • HARLING, John, David [GB/GB]; GB (UsOnly)
Inventors
  • ORLEK, Barry, Sidney; GB
  • HARLING, John, David; GB
Agents
  • FLORENCE, Julia, Anne; SmithKline Beecham Corporate Intellectual Property SB House, Great West Road Brentford, Middlesex TW8 9BD, GB
  • GIDDINGS, Peter, J.; Corporate Patents SmithKline Beecham Mundells Welwyn Garden City Hertfordshire AL7 1EY, GB
Priority Data
08/455,77631.05.1995US
08/455,81231.05.1995US
9414184.314.07.1994GB
9500688.813.01.1995GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) BENZOCYCLOALKYLAMINE DERIVATIVES AS CALCIUM CHANNEL ANTAGONISTS
(FR) DERIVES DE BENZOCYCLOALCOYLAMINE UTILES COMME ANTAGONISTES DU CANAL A CALCIUM
Abstract
(EN)
Compounds of formula (I), wherein n is 1, 2 or 3; R1 and R2 each independently represent hydrogen, C1-6alkyl, C3-6cycloalkyl, or C3-6cycloalkylC1-4alkyl; p and q independently represent 0-4; X represents O, S, NH or, provided that the sum of p and q is at least 1, a bond; and Ar represents phenyl substituted by -Y-CR3R4-Ph, where Y is oxygen or a bond, R3 and R4 are indenpendently, H, methyl or ethyl, provided that R3 and R4 are not both H, and Ph is optionally substituted phenyl; and salts thereof are calcium channel antagonists useful in the treatment of ischaemic conditions e.g. stroke.
(FR)
Composés de formule (I), dans laquelle n vaut 1, 2 ou 3; R1 et R2 désignent indépendamment hydrogène, alcoyle C1-6, cycloalcoyle C3-6 ou alcoyle C1-4 cycloalcoyle C3-6; p et q représentent indépendamment 0 à 4; X désigne O, S, NH ou une liaison, à condition que la somme de p et q soit au moins 1; et Ar désigne phényle substitué par -Y-CR3R4-Ph, où Y désigne oxygène ou une liaison; R3 et R4 désignent indépendamment l'un de l'autre H, méthyle ou éthyle, à condition que R3 et R4 ne désignent pas tous les deux H; et Ph représente phényle éventuellement substitué. Ces composés et leurs sels constituent des antagonistes du canal à calcium utiles dans le traitement d'états ischémiques tels que l'apoplexie.
Also published as
Latest bibliographic data on file with the International Bureau