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1. WO1996002488 - METHOD OF STABILIZING POLYUNSATURATED FATTY ACIDS AND THEIR APPLICATION IN THERAPY AND COSMETICS

Publication Number WO/1996/002488
Publication Date 01.02.1996
International Application No. PCT/FR1995/000949
International Filing Date 17.07.1995
IPC
A61K 9/14 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
A61K 31/202 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
20having a carboxyl group bound to an acyclic chain of seven or more carbon atoms, e.g. stearic, palmitic or arachidic acid
202having three or more double bonds, e.g. linolenic acid
A61K 31/232 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
23of acids having a carboxyl group bound to a chain of seven or more carbon atoms
232having three or more double bonds, e.g. etretinate
C07C 51/50 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
51Preparation of carboxylic acids or their salts, halides, or anhydrides
42Separation; Purification; Stabilisation; Use of additives
50Use of additives, e.g. for stabilisation
CPC
A61K 31/202
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
20having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
202having three or more double bonds, e.g. linolenic
A61K 31/232
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
215of carboxylic acids
22of acyclic acids, e.g. pravastatin
23of acids having a carboxyl group bound to a chain of seven or more carbon atoms
232having three or more double bonds, e.g. etretinate
A61K 9/146
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
141Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
146with organic macromolecular compounds
A61P 17/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
17Drugs for dermatological disorders
C07C 51/50
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
CACYCLIC OR CARBOCYCLIC COMPOUNDS
51Preparation of carboxylic acids or their salts, halides or anhydrides
42Separation; Purification; Stabilisation; Use of additives
50Use of additives, e.g. for stabilisation
Applicants
  • GRINDA, Jean-Robert [FR/FR]; FR
Inventors
  • GRINDA, Jean-Robert; FR
Agents
  • BURTIN, Jean-François; Cabinet GEFIB 85, rue Anatole-France F-92300 Levallois-Perret, FR
Priority Data
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) METHOD OF STABILIZING POLYUNSATURATED FATTY ACIDS AND THEIR APPLICATION IN THERAPY AND COSMETICS
(FR) PROCEDE DE STABILISATION DES ACIDES GRAS POLY-INSATURES ET UTILISATION DE CES PRODUITS STABILISES EN THERAPEUTIQUE ET EN COSMETOLOGIE
Abstract
(EN)
The invention concerns the field of chemistry, in particular therapeutical chemistry and provides a method for the stabilization of non-saturated fatty acids or their lower alkyl esters. The method comprises the steps of mixing a solution comprising the above-mentioned acids or esters in a non-hydroxylated inert solvent, with a cellulose hydroxyalkyl and then desolvating such a preparation in order to pulverize it. The preparation is then diluted or mixed with a pharmaceutically acceptable non-toxic inert carrier or excipient for preparing pharmaceutical formulations or with an inert diluent or carrier for cosmetic formulations.
(FR)
L'invention concerne le domaine de la chimie et notamment de la chimie thérapeutique. Elle concerne un procédé de stabilisation d'acides gras non saturés ou de leurs esters d'alcoyle inférieur, qui consiste à mélanger une solution de celui-ci dans un solvant inerte non hydroxylé, avec une hydroxyalcoyl cellulose, puis à dessolvater une telle préparation pour la rendre parfaitement pulvérulente. Cette préparation est ensuite diluée ou mélangée à un véhicule ou à un excipient inerte non toxique pharmaceutiquement acceptable en vue de la réalisation de compositions pharmaceutiques ou avec un diluant ou un véhicule inerte en vue de la réalisation de compositions cosmétiques.
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