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1. WO1996002271 - ELECTRICALLY HYDROLYZED SALINES AS IN VIVO MICROBICIDES FOR THE TREATMENT OF CARDIOMYOPATHY AND MULTIPLE SCLEROSIS

Publication Number WO/1996/002271
Publication Date 01.02.1996
International Application No. PCT/US1994/008280
International Filing Date 22.07.1994
Chapter 2 Demand Filed 05.02.1996
IPC
A61K 33/40 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
40Peroxides
A61K 33/42 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
42Phosphorus; Compounds thereof
A61K 35/08 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
02from inanimate materials
08Mineral waters; Seawater
A61K 38/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
06Tripeptides
A61K 38/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
43Enzymes; Proenzymes; Derivatives thereof
44Oxidoreductases (1)
A61L 2/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
2Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
CPC
A23L 29/37
AHUMAN NECESSITIES
23FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
LFOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A23B - A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT
29Foods or foodstuffs containing additives
30containing carbohydrate syrups; containing sugars; containing sugar alcohols, e.g. xylitol; containing starch hydrolysates, e.g. dextrin
37Sugar alcohols
A61K 31/715
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
70Carbohydrates; Sugars; Derivatives thereof
715Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
A61K 33/40
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
40Peroxides
A61K 33/42
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
33Medicinal preparations containing inorganic active ingredients
42Phosphorus; Compounds thereof
A61K 35/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35Medicinal preparations containing materials or reaction products thereof with undetermined constitution
02from inanimate materials
08Mineral waters; Sea water
A61K 38/063
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
06Tripeptides
063Glutathione
Applicants
  • MEDICAL DISCOVERIES, INC. [US/US]; Suite 209 55 North Main Logan, UT 84321, US
Inventors
  • MORROW, Robert, E.; US
Agents
  • WESTERN, M., Wayne ; Thorpe, North & Western Suite 200 9035 South 700 East Sandy, UT 84070, US
Priority Data
08/275,90415.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ELECTRICALLY HYDROLYZED SALINES AS IN VIVO MICROBICIDES FOR THE TREATMENT OF CARDIOMYOPATHY AND MULTIPLE SCLEROSIS
(FR) SOLUTIONS SALINES HYDROLYSEES DE FAÇON ELECTRIQUE EN TANT QUE MICROBICIDES IN VIVO DESTINES AU TRAITEMENT DE LA CARDIOMYOPATHIE ET DE LA SCLEROSE EN PLAQUE
Abstract
(EN)
A microbiocidal solution for $i(in vivo) and $i(in vitro) treatment of microbial infections comprises an electrolyzed saline containing regulated amounts of ozone and active chlorine species wherein the ozone content is between about 5 and 100 mg/L and the active chlorine species content of between about 5 and 300 ppm. The active chlorine species comprises free chlorine, hypochlorous acid and the hypochlorite ion as measured by a chlorine selective electrode. The solution is prepared by subjecting a 1 % or less saline to electrolysis under conditions sufficient to produce the desired active ingredients. The solution is preferably utilized at an isotonic saline concentration and may be adjusted with hypertonic saline. The solution may be used for the $i(in vitro) treatment of infected whole blood, blood cells or plasma to reduce contamination and is effective in treatment of fluids infected with HIV, hepatitis and other viral, bacterial and fungal agents. The solution may also be administered to warm blooded animals, including humans, by intravenous injection or other modes for similar purposes. If desired, neutralizing agents, such as antioxidants, may be administered in correlation with the solution.
(FR)
Solution microbicide destinée à un traitement $i(in vivo) et $i(in vitro) d'infections microbiennes, comprenant une solution saline électrolysée contenant des quantités régulées d'ozone et d'espèce chlorée active, solution dans laquelle la teneur en ozone est comprise entre 5 et 100 mg/L et la teneur en espèce chlorée est comprise entre 5 et 300 ppm. L'espèce chlorée active comprend du chlore libre, de l'acide hypochloreux ainsi qu'un ion d'hypochlorite tel que mesuré par une électrode sélective du chlore. On prépare la solution en soumettant à une électrolyse une solution saline à 1 % ou moins, dans des conditions suffisantes pour produire les ingrédients actifs souhaités. De préférence, on utilise la solution à une concentration saline isotonique et on peut l'ajuster à l'aide d'une solution saline hypertonique. On peut utiliser cette solution pour un traitement $i(in vitro) de sang entier, de cellules sanguines ou de plasma infectés afin de réduire la contamination, cette solution étant efficace dans le traitement de fluides infectés par le VIH, l'hépatite ainsi que par d'autres agents viraux, bactériens et fongiques. On peut également administrer la solution à des animaux à sang chaud, notamment aux humains, par injection intraveineuse ou à l'aide d'autre modes destinés à des fins analogues. Si nécessaire, on peut administrer en corrélation avec la solution des agents neutralisants tels que des antioxydants.
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