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1. WO1996002268 - INHIBITION OF VIRUS BY NITRIC OXIDE

Publication Number WO/1996/002268
Publication Date 01.02.1996
International Application No. PCT/US1995/008763
International Filing Date 13.07.1995
Chapter 2 Demand Filed 21.12.1995
IPC
A61K 31/198 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid (GABA), beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-amino acids, e.g. alanine, edetic acid (EDTA)
A61K 31/21 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
A61K 31/401 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
401Proline; Derivatives thereof, e.g. captopril
A61K 31/426 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
425Thiazoles
4261,3-Thiazoles
A61K 38/05 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05Dipeptides
A61K 38/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
06Tripeptides
CPC
A61K 31/198
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
195having an amino group
197the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid, pantothenic acid
198Alpha-aminoacids, e.g. alanine, edetic acids [EDTA],
A61K 31/21
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
21Esters, e.g. nitroglycerine, selenocyanates
A61K 31/401
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
40having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
401Proline; Derivatives thereof, e.g. captopril
A61K 31/426
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
41having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
425Thiazoles
4261,3-Thiazoles
A61K 38/05
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
05Dipeptides
A61K 38/063
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
06Tripeptides
063Glutathione
Applicants
  • BRIGHAM AND WOMEN'S HOSPITAL [US/US]; 75 Francis Street Boston, MA 02115, US
Inventors
  • STAMLER, Jonathan; US
  • MANNICK, Joan; US
Agents
  • HERRON, Charles, J. ; Carella, Byrne, Bain, Gilfillan, Cecchi, Stewart & Olstein 6 Becker Farm Road Roseland, NJ 07068, US
Priority Data
08/276,05715.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INHIBITION OF VIRUS BY NITRIC OXIDE
(FR) INHIBITION D'UN VIRUS PAR L'OXYDE NITRIQUE
Abstract
(EN)
A method for inhibiting the replication of a virus by exposing the virus to nitric oxide or a nitric oxide releasing, delivering or transferring substance, particularly administering a virus replication inhibitory amount of nitric oxide or a nitric oxide releasing substance to an individual having a virus infection. A method for preventing of reversing latency in a virus by exposing the latent virus to a nitric oxide synthase inhibitor, particularly a method for the treatment of a latent virus infection in an individual by administering (i) a virus latency preventing or reversing amount of a nitric oxide synthase inhibitor sufficient to render the virus replicative and then (ii) a virus replication inhibitory amount of nitric oxide or a nitric oxide-releasing substance and a composition of (i) and (ii) for such treatment, (iii) a prophylactic amount of NO(ii) to prevent latent virus from becoming replicative.
(FR)
L'invention se rapporte à un procédé d'inhibition de la réplication d'un virus consistant à soumettre le virus à l'oxyde nitrique ou à une substance libérant, délivrant ou transférant de l'oxyde nitrique, et notamment à administrer une quantité, inhibant la réplication du virus, d'oxyde nitrique ou d'une substance libérant de l'oxyde nitrique à un patient infecté par un virus. L'invention se rapporte également à un procédé inhibant ou inversant la latence d'un virus en soumettant le virus latent à un inhibiteur de synthase de l'oxyde nitrique, et notamment à un procédé de traitement d'une infection due au virus latent consistant à administrer à un patient (i) une quantité suffisante, inhibant ou inversant la latence du virus, d'inhibiteur de synthase de l'oxyde nitrique pour que le virus se réplique, puis (ii) une quantité, inhibant la réplication du virus, d'oxyde nitrique ou d'une substance libérant de l'oxyde nitrique, et une composition de (i) et (ii) appliquée dans ce traitement, et (iii) une quantité prophylactique de NO(ii) pour empêcher le virus latent de se répliquer.
Also published as
Latest bibliographic data on file with the International Bureau