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1. WO1996002249 - USE OF THIAZOLE AND THIADIAZOLE COMPOUNDS AS D3 DOPAMINE RECEPTOR LIGANDS

Publication Number WO/1996/002249
Publication Date 01.02.1996
International Application No. PCT/EP1995/002783
International Filing Date 14.07.1995
Chapter 2 Demand Filed 18.01.1996
IPC
A61K 31/4439 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/454 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
445Non-condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/496 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
C07D 277/36 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
32with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36Sulfur atoms
C07D 285/125 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
285Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/-C07D283/183
01Five-membered rings
02Thiadiazoles; Hydrogenated thiadiazoles
04not condensed with other rings
121,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
125with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
C07D 285/135 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
285Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/-C07D283/183
01Five-membered rings
02Thiadiazoles; Hydrogenated thiadiazoles
04not condensed with other rings
121,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
125with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
135Nitrogen atoms
CPC
A61K 31/4439
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
4427containing further heterocyclic ring systems
4439containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
A61K 31/454
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
445Non condensed piperidines, e.g. piperocaine
4523containing further heterocyclic ring systems
454containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
A61K 31/496
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
495having six-membered rings with two ; or more; nitrogen atoms as the only ring heteroatoms, e.g. piperazine ; or tetrazines
496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
C07D 277/36
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
277Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
02not condensed with other rings
20having two or three double bonds between ring members or between ring members and non-ring members
32with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
36Sulfur atoms
C07D 285/125
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
285Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
01Five-membered rings
02Thiadiazoles; Hydrogenated thiadiazoles
04not condensed with other rings
121,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
125with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
C07D 285/135
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
285Heterocyclic compounds containing rings having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by groups C07D275/00 - C07D283/00
01Five-membered rings
02Thiadiazoles; Hydrogenated thiadiazoles
04not condensed with other rings
121,3,4-Thiadiazoles; Hydrogenated 1,3,4-thiadiazoles
125with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
135Nitrogen atoms
Applicants
  • BASF AKTIENGESELLSCHAFT [DE/DE]; D-67056 Ludwigshafen, DE (AllExceptUS)
  • HELLENDAHL, Beate [DE/DE]; DE (UsOnly)
  • LANSKY, Annegret [DE/DE]; DE (UsOnly)
  • RENDENBACH-MÜLLER, Beatrice [DE/DE]; DE (UsOnly)
  • BACH, Alfred [DE/DE]; DE (UsOnly)
  • UNGER, Liliane [DE/DE]; DE (UsOnly)
  • TESCHENDORF, Hans-Jürgen [DE/DE]; DE (UsOnly)
  • WICKE, Karsten [DE/DE]; DE (UsOnly)
Inventors
  • HELLENDAHL, Beate; DE
  • LANSKY, Annegret; DE
  • RENDENBACH-MÜLLER, Beatrice; DE
  • BACH, Alfred; DE
  • UNGER, Liliane; DE
  • TESCHENDORF, Hans-Jürgen; DE
  • WICKE, Karsten; DE
Agents
  • KINZEBACH, Werner ; Reitstötter, Kinzebach & Partner Postfach 86 06 49 D-81633 München, DE
Priority Data
P 44 25 145.915.07.1994DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) VERWENDUNG VON THIAZOL- UND THIADIAZOLVERBINDUNGEN ALS D3 DOPAMINREZEPTORLIGAND
(EN) USE OF THIAZOLE AND THIADIAZOLE COMPOUNDS AS D3 DOPAMINE RECEPTOR LIGANDS
(FR) UTILISATION DE COMPOSES DE THIAZOLE ET DE THIADIAZOLE COMME LIGANDS DU RECEPTEUR DE LA DOPAMINE D3
Abstract
(DE)
Die vorliegende Erfindung betrifft die Verwendung von Thiazol- und Thiadiazolverbindungen der Formel (I), worin R1, A, B, und Ar die in der Beschreibung angegebenen Bedeutungen besitzen. Die erfindungsgemäßen Verbindungen besitzen eine hohe Affinität zum Dopamin-D3-Rezeptor und sind daher zur Behandlung von Erkrankungen des zentralen Nervensystems brauchbar.
(EN)
The use is disclosed of thiazole and thiadiazole compounds having the formula (I), in which R1, A, B and Ar have the meanings given in the description. These compounds have a high affinity to the dopamine D3 receptor and are therefore useful for treating diseases of the central nervous system.
(FR)
L'utilisation concerne l'utilisation de composés de thiazole et de thiadiazole correspondant à la formule (I), dans laquelle R1, A, B et Ar ont la signification donnée dans la description. Ces composés ont une affinité élevée avec le récepteur de la dopamine D3 et sont par conséquent utiles pour traiter des maladies du système nerveux central.
Also published as
CZPV1997-94
FI970149
NO19970164
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