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1. WO1996002238 - NEUROTROPIC AND SEDATIVE AGENT AND A METHOD OF OBTAINING THE SAME

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Publication Number WO/1996/002238
Publication Date 01.02.1996
International Application No. PCT/RU1995/000155
International Filing Date 14.07.1995
IPC
A61K 9/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A61K 9/28 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
28Dragees; Coated pills or tablets
A61K 31/44 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non-condensed pyridines; Hydrogenated derivatives thereof
CPC
A61K 31/44
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
33Heterocyclic compounds
395having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
435having six-membered rings with one nitrogen as the only ring hetero atom
44Non condensed pyridines; Hydrogenated derivatives thereof
A61K 9/2009
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2004Excipients; Inactive ingredients
2009Inorganic compounds
A61K 9/2866
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
28Dragees; Coated pills or tablets ; , e.g. with film or compression coating
2806Coating materials
2833Organic macromolecular compounds
286Polysaccharides, e.g. gums; Cyclodextrin
2866Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
Applicants
  • AKTSIONERNOE OBSCHESTVO ZAKRYTOGO TIPA 'OLVIK' [RU/RU]; ul. Nezhdanovoi, 11-607 Moscow, 103009, RU (AllExceptUS)
  • SMIRNOV, Leonid Dmitrievich [RU/RU]; RU (UsOnly)
  • VORONINA, Tatyana Alexandrovna [RU/RU]; RU (UsOnly)
  • DJUMAEV, Kirill Mikhailovich [RU/RU]; RU (UsOnly)
  • BUROV, Jury Valentinovich [RU/RU]; RU (UsOnly)
Inventors
  • SMIRNOV, Leonid Dmitrievich; RU
  • VORONINA, Tatyana Alexandrovna; RU
  • DJUMAEV, Kirill Mikhailovich; RU
  • BUROV, Jury Valentinovich; RU
Priority Data
9402685615.07.1994RU
Publication Language Russian (RU)
Filing Language Russian (RU)
Designated States
Title
(EN) NEUROTROPIC AND SEDATIVE AGENT AND A METHOD OF OBTAINING THE SAME
(FR) AGENT NEUROTROPE ET SEDATIF ET SON PROCEDE D'OBTENTION
Abstract
(EN)
The proposed neurotropic and sedative substance contains mexidol and a carrier and is in the form of a tablet with a core containing 16.7-41.6 % by weight mexidol and auxiliary agents and a polymer coating. The auxiliary agents in the core comprise kaolin (16.7-33.3 %), potato starch (16.7-33.3 %), calcium stearate (0.3-0.5 %), stearic acid (0.3-0.5 %), talc (0.5-1.00 %), and methyl cellulose (25.0-50.0 %). The proposed method of obtaining this neurotropic and sedative substance in the form of a coated tablet involves mixing mexidol, starch and kaolin together and adding a methyl cellulose solution, granulating, drying and dusting the mixture with calcium stearate and stearic acid, pressing it into tablets and treating it with a solution of methyl cellulose in alcohol, titanium dioxide and serge 80.
(FR)
La substance neurotrope et sédative de l'invention contient du mexidol ainsi qu'un excipient, elle se présente sous la forme d'un comprimé présentant une âme contenant 16,7 à 41,6 % en poids de mexidol ainsi que des agents auxiliaires et un enrobage en polymère. Les agents auxiliaires se trouvant dans l'âme comprennent du kaolin (16,7 à 33,3 %), de l'amidon de pomme de terre (16,7 à 33,3 %), du stéarate de calcium (0,3 à 0,5 %), de l'acide stéarique (0,3 à 0,5 %), du talc (0,5 à 1,00 %), ainsi que de la méthylcellulose (25,0 à 50,0 %). Le procédé proposé d'obtention de cette substance neurotrope et sédative sous la forme d'un comprimé enrobé consiste à mélanger du mexidol, de l'amidon et du kaolin ensemble et à ajouter une solution de méthylcellulose, à granule, à sécher et à réduire en poudre le mélange avec du stéarate de calcium et de l'acide stéarique, à le comprimer afin de former des comprimés puis à le traiter avec une solution de méthylcellulose dans de l'alcool, du dioxide de titane et de la serge 80.
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