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1. WO1996002236 - IMPROVED COMBINATION DOSE UNIT

Publication Number WO/1996/002236
Publication Date 01.02.1996
International Application No. PCT/AU1995/000434
International Filing Date 18.07.1995
Chapter 2 Demand Filed 20.02.1996
IPC
A61K 9/20 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, lozenges or tablets
A61K 9/50 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules
A61K 45/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
B01J 13/10 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02Making microcapsules or microballoons
06by phase separation
10Complex coacervation, i.e. interaction of oppositely charged particles
CPC
A61K 45/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
06Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
A61K 9/2081
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
20Pills, tablets, ; discs, rods
2072characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
2077Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
2081with microcapsules or coated microparticles according to A61K9/50
A61K 9/5089
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
48Preparations in capsules, e.g. of gelatin, of chocolate
50Microcapsules ; having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
5089Processes
B01J 13/10
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
13Colloid chemistry, e.g. the production of colloidal materials or their solutions, not otherwise provided for; Making microcapsules or microballoons
02Making microcapsules or microballoons
06by phase separation
10Complex coacervation, i.e. interaction of oppositely charged particles
Applicants
  • MOORE, Trevor [AU/AU]; AU
  • BORODY, Thomas, Julius [AU/AU]; AU
Inventors
  • MOORE, Trevor; AU
  • BORODY, Thomas, Julius; AU
Agents
  • SHELSTON WATERS; 60 Margaret Street Sydney, NSW 2000, AU
Priority Data
PM 695220.07.1994AU
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVED COMBINATION DOSE UNIT
(FR) DOSE UNITAIRE AMELIOREE POUR THERAPIE D'ASSOCIATION
Abstract
(EN)
This invention relates to a combination therapy dose unit and a method of preparing such a dose unit. The method of preparation is designed to prevent interaction between a plurality of active agents in a combination therapy dose unit, and comprises the steps of charging particles of an active agent, charging particles of an inert particulate medium with a charge of opposite polarity to that of the charged particles of the active agent and allowing the charged inert particulate medium particles to electrostatically adhere to the charged particles of the active agent, thereby to coat the active agent with inert particulate medium. Thereafter other active agents can be treated in a similar manner and the electrostatically coated active agents can be combined, and may include other non-coated active agents, into a single combination therapy dose unit such as a tablet.
(FR)
L'invention se rapporte à une dose unitaire pour thérapie d'association, et à un procédé de préparation de cette dose. Ce procédé est conçu pour prévenir toute interaction entre une pluralité d'agents actifs dans une dose unitaire de thérapie d'association, et consiste à charger des particules d'un agent actif, à charger des particules d'un milieu particulaire inerte d'une charge de polarité opposée à celle des particules d'agent actif, et à laisser adhérer par voie électrostatique les particules chargées du milieu inerte aux particules chargées de l'agent actif, de façon à enrober ces dernières du milieu particulaire inerte. D'autres agents actifs peuvent ensuite être traités de manière analogue et les agents actifs à enrobage électrostatique peuvent être associés, éventuellement avec d'autres agents actifs non enrobés, en une dose unitaire unique de thérapie d'association, telle qu'un comprimé.
Also published as
Latest bibliographic data on file with the International Bureau