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1. WO1996002235 - INJECTABLE RES AVOIDING INORGANIC PARTICLES

Publication Number WO/1996/002235
Publication Date 01.02.1996
International Application No. PCT/US1995/008861
International Filing Date 14.07.1995
IPC
A61K 49/18 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance (NMR) contrast preparations; Magnetic resonance imaging (MRI) contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
CPC
A61K 47/6923
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
69the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
6921the form being a particulate, a powder, an adsorbate, a bead or a sphere
6923the form being an inorganic particle, e.g. ceramic particles, silica particles, ferrite or synsorb
A61K 49/1812
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1806Suspensions, emulsions, colloids, dispersions
1812liposomes, polymersomes, e.g. immunoliposomes
A61K 49/183
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1821coated or functionalised microparticles or nanoparticles
1824coated or functionalised nanoparticles
1827having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
183having a (super)(para)magnetic core coated or functionalised with an inorganic material or being composed of an inorganic material entrapping the MRI-active nucleus, e.g. silica core doped with a MRI-active nucleus
A61K 49/1854
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1821coated or functionalised microparticles or nanoparticles
1824coated or functionalised nanoparticles
1827having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
1851having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
1854the organic macromolecular compound being obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly(meth)acrylate, polyacrylamide, polyvinylpyrrolidone, polyvinylalcohol
A61K 49/186
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
49Preparations for testing in vivo
06Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
18characterised by a special physical form, e.g. emulsions, microcapsules, liposomes
1818particles, e.g. uncoated or non-functionalised microparticles or nanoparticles
1821coated or functionalised microparticles or nanoparticles
1824coated or functionalised nanoparticles
1827having a (super)(para)magnetic core, being a solid MRI-active material, e.g. magnetite, or composed of a plurality of MRI-active, organic agents, e.g. Gd-chelates, or nuclei, e.g. Eu3+, encapsulated or entrapped in the core of the coated or functionalised nanoparticle
1851having a (super)(para)magnetic core coated or functionalised with an organic macromolecular compound, i.e. oligomeric, polymeric, dendrimeric organic molecule
1857the organic macromolecular compound being obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. PLGA
186the organic macromolecular compound being polyethyleneglycol [PEG]
A61K 9/1272
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
10Dispersions; Emulsions
127Liposomes
1271Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
1272with substantial amounts of non-phosphatidyl, i.e. non-acylglycerophosphate, surfactants as bilayer-forming substances, e.g. cationic lipids
Applicants
  • BIOQUEST, INCORPORATED [US/US]; 8 Commerce Drive Atkinson, NH 03811, US
Inventors
  • CHAGNON, Mark, S.; US
  • BURKLE, Stephen, E.; US
  • CARTER, Michelle, J.; US
  • HAMILTON, Tracy, J.; US
  • HAVELICK, John, Jr.; US
  • KAPLAN, Deborah, A.; US
  • MARZLOFF, Kristin, L.; US
Agents
  • SOLOWAY, Norman, P.; Hayes, Soloway, Hennessey, Grossman & Hage 175 Canal Street Manchester, NH 03101, US
Priority Data
08/277,65520.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) INJECTABLE RES AVOIDING INORGANIC PARTICLES
(FR) PARTICULES INORGANIQUES INJECTABLES EVITANT LE SRE
Abstract
(EN)
Novel N-RES agents for use in vitro and in vivo medical and biological applications, such as, for example MRI and/or intravenous administration of pharmaceutical agents are described. The novel N-RES agents are prepared by coating inorganic core particles with a poly(acrylic acid) - poly(alkylene ether) graft copolymer. The resulting polymer-coated inorganic particle cores are useful as imaging agents, therapeutic agents or carriers having increased circulation time due to decrease uptake or recognition by the RES.
(FR)
L'invention concerne de nouveaux agents évitant le SRE (système réticuloendothélial), prévus pour être utilisés in vitro et in vivo dans des applications médicales et biologiques, par exemple, en imagerie par résonance magnétique et/ou lors de l'administration par voie intraveineuse d'agents pharmaceutiques. Ces nouveaux agents sont préparés en enrobant des particules-coeurs inorganiques avec un copolymère greffé d'éther (poly)alkylène - acide (poly)acrylique. Les coeurs des particules inorganiques enrobés de polymères ainsi obtenus peuvent être utilisés comme agents d'imagerie, comme agents thérapeutiques ou de supports dont le temps de circulation est plus important en raison de la diminution de l'absorption ou de la reconnaissance par le SRE.
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