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1. WO1996002140 - ISOLATED p27 PROTEIN AND METHODS FOR ITS PRODUCTION AND USE

Publication Number WO/1996/002140
Publication Date 01.02.1996
International Application No. PCT/US1995/007361
International Filing Date 07.06.1995
Chapter 2 Demand Filed 13.02.1996
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/47 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 14/4738
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
14Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435from animals; from humans
46from vertebrates
47from mammals
4701not used
4738Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
Applicants
  • SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH [US/US]; 1275 York Avenue New York, NY 10021, US (AllExceptUS)
  • FRED HUTCHINSON CANCER RESEARCH CENTER [US/US]; 1124 Columbia Street Seattle, WA 98104, US (AllExceptUS)
  • MASSAGUE, Joan [US/US]; US (UsOnly)
  • ROBERTS, James, M. [US/US]; US (UsOnly)
  • KOFF, Andrew [US/US]; US (UsOnly)
  • POLYAK, Kornelia [HU/US]; US (UsOnly)
Inventors
  • MASSAGUE, Joan; US
  • ROBERTS, James, M.; US
  • KOFF, Andrew; US
  • POLYAK, Kornelia; US
Agents
  • VINCENT, Matthew, P. ; Lahive & Cockfield 60 State Street Boston, MA 02109, US
Priority Data
08/275,98315.07.1994US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ISOLATED p27 PROTEIN AND METHODS FOR ITS PRODUCTION AND USE
(FR) PROTEINE ISOLEE p27 ET PROCEDES POUR SA PRODUCTION ET SON UTILISATION
Abstract
(EN)
An isolated protein designated p27 is disclosed. The p27 protein has an apparent molecular weight of about 27 kD, and is capable of binding to and inhibiting the activation of a cyclin E - Cdk2 complex. A nucleic acid sequence encoding p27 protein is disclosed, as well as a method for producing p27 in cultured cells. $i(in vitro) assays for discovering agents which effect the activity of p27 are also provided. Methods of diagnosing and treating hypoproliferative and hyperproliferative disorders are provided.
(FR)
La présente invention concerne une protéine isolée dénommée p27. La protéine p27 est caractérisée par une masse moléculaire apparent d'environ 27 kD, et elle est capable de se lier à un complexe cycline E - Cdk2 et d'en inhiber l'activation. L'invention concerne également une séquence d'acides nucléiques codant la protéine p27 ainsi qu'un procédé de production de la p27 dans des cellules de culture. L'invention concerne en outre des dosages in vitro permettant de découvrir des agents affectant l'activité de la p27. L'invention concerne enfin des procédés de diagnostic et de traitement des troubles de l'hypoprolifération et de l'hyperprolifération.
Also published as
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