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1. WO1995035321 - ANTIBODIES AGAINST T-CELLS AS THERAPEUTICS

Publication Number WO/1995/035321
Publication Date 28.12.1995
International Application No. PCT/EP1995/001898
International Filing Date 19.05.1995
Chapter 2 Demand Filed 05.12.1995
IPC
A61K 47/48 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
48the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 47/6849
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
50the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
51the non-active ingredient being a modifying agent
68the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
6835the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
6849the antibody targeting a receptor, a cell surface antigen or a cell surface determinant
A61P 35/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35Antineoplastic agents
A61P 37/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
02Immunomodulators
06Immunosuppressants, e.g. drugs for graft rejection
C07K 16/2812
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2812against CD4
C07K 16/2815
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2815against CD8
Y10S 530/868
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
530Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
868involving autoimmunity, allergy, immediate hypersensitivity, delayed hypersensitivity, immunosuppression, or immunotolerance
Applicants
  • GSF - FORSCHUNGSZENTRUM FÜR UMWELT UND GESUNDHEIT GMBH [DE]/[DE] (AllExceptUS)
  • THIERFELDER, Stefan [DE]/[DE] (UsOnly)
Inventors
  • THIERFELDER, Stefan
Agents
  • VOSSIUS & PARTNER
Priority Data
P 44 21 391.318.06.1994DE
Publication Language German (DE)
Filing Language German (DE)
Designated States
Title
(DE) ANTIKÖRPER GEGEN T-ZELLEN ALS THERAPEUTIKUM
(EN) ANTIBODIES AGAINST T-CELLS AS THERAPEUTICS
(FR) ANTICORPS AGISSANT CONTRE LES CELLULES T, UTILISES COMME AGENTS THERAPEUTIQUES
Abstract
(DE)
Die Erfindung betrifft Antikörper gegen T-Zellen als Therapeutikum. Aufgabe der Erfindung ist es, Antikörper für eine klinische Therapie zur Verlängerung der immunsuppressiven Antikörperwirkung unter Vermeidung von Anti-antikörperbildung zur Verfügung zu stellen. Gelöst wird diese Aufgabe durch Antikörper, welche aus mindestens zwei verschiedenen Gruppen bestehen, welche zeitlich von einander getrennt verabreicht werden und bei welchen sich mindestens ein Antikörper aus der Gruppe B in den konstanten Teilen der schweren Ketten von einem Antikörper der Gruppe A unterscheidet und wobei die Gruppe A, welche als erste einmal oder mehrmals appliziert wird, T-Zelleliminierend wirkt, während die weitere Gruppe B (welche in zeitlichem Abstand appliziert wird) T-Zelleliminierend und/oder T-Zellantigen-modulierend wirkt.
(EN)
The invention relates to antibodies against T-cells as therapeutics. It is the aim of the invention to provide antibodies for clinical therapy to prolong the immunosuppressive antibody effect while preventing the formation of anti-antibodies. This is attained by antibodies consisting of at least two different groups which are administered separately in time and in which at least one antibody from group B is distinguished in the constant parts of the heavy chains of an antibody of group A and in which group A, which is applied once or several times as the first one, has a T-cell eliminating action, while the further group B (which is applied after a time lapse) has a T-cell eliminating and/or T-cell antigen modulating effect.
(FR)
L'invention vise à préparer des anticorps pour une thérapie clinique, qui permettent de prolonger l'effet immunosuppresseur des anticorps, tout en évitant la formation d'anti-anticorps. A cet effet, on utilise des anticorps qui comprennent au moins deux groupes différents qui sont administrés séparément dans le temps et dans lesquels au moins un anticorps du groupe B se distingue, dans les parties constantes des chaînes lourdes, d'un anticorps du groupe A, et où le groupe A qui est appliqué le premier une ou plusieurs fois, possède une action éliminatrice des cellules T, alors que le groupe B (qui est appliqué après un intervalle de temps) possède une action éliminatrice des cellules T et/ou une action modulatrice de l'antigène des cellules T.
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