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1. WO1995033433 - METHOD FOR THE PREPARATION OF PEARLS AND PEARLS OBTAINED CONTAINING AN ACTIVE INGREDIENT WITH AN UNDEFINED MELTING POINT

Publication Number WO/1995/033433
Publication Date 14.12.1995
International Application No. PCT/FR1995/000717
International Filing Date 01.06.1995
Chapter 2 Demand Filed 07.12.1995
IPC
A61J 3/06 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
3Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
06into the form of pills, lozenges or dragees
A61K 9/16 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders
16Agglomerates; Granulates; Microbeadlets
B01J 2/04 2006.01
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2Processes or devices for granulating materials, in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
02by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
04in a gaseous medium
CPC
A61J 3/06
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
JCONTAINERS SPECIALLY ADAPTED FOR MEDICAL OR PHARMACEUTICAL PURPOSES; DEVICES OR METHODS SPECIALLY ADAPTED FOR BRINGING PHARMACEUTICAL PRODUCTS INTO PARTICULAR PHYSICAL OR ADMINISTERING FORMS; DEVICES FOR ADMINISTERING FOOD OR MEDICINES ORALLY; BABY COMFORTERS; DEVICES FOR RECEIVING SPITTLE
3Devices or methods specially adapted for bringing pharmaceutical products into particular physical or administering forms
06into the form of pills, lozenges or dragees
A61K 9/1617
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
1605Excipients; Inactive ingredients
1617Organic compounds, e.g. phospholipids, fats
A61K 9/167
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
14Particulate form, e.g. powders, ; Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
16Agglomerates; Granulates; Microbeadlets ; ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
167with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
B01J 2/04
BPERFORMING OPERATIONS; TRANSPORTING
01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
JCHEMICAL OR PHYSICAL PROCESSES, e.g. CATALYSIS OR COLLOID CHEMISTRY; THEIR RELEVANT APPARATUS
2Processes or devices for granulating materials ; , e.g. fertilisers; in general; Rendering particulate materials free flowing in general, e.g. making them hydrophobic
02by dividing the liquid material into drops, e.g. by spraying, and solidifying the drops
04in a gaseous medium
Applicants
  • RHONE-POULENC RORER S.A. [FR]/[FR] (AllExceptUS)
  • DELEUIL, Michel [FR]/[FR] (UsOnly)
  • LE THIESSE, Jean-Claude [FR]/[FR] (UsOnly)
Inventors
  • DELEUIL, Michel
  • LE THIESSE, Jean-Claude
Agents
  • LOBJOIS, Françoise
Priority Data
94/0684203.06.1994FR
Publication Language French (FR)
Filing Language French (FR)
Designated States
Title
(EN) METHOD FOR THE PREPARATION OF PEARLS AND PEARLS OBTAINED CONTAINING AN ACTIVE INGREDIENT WITH AN UNDEFINED MELTING POINT
(FR) PROCEDE DE PREPARATION ET PERLES OBTENUES CONTENANT UN PRINCIPE ACTIF PRESENTANT UN POINT DE FUSION NON DEFINI
Abstract
(EN)
Novel method for the preparation of pearls from a compound with an undefined crystallization point having fast and/or sustained release properties. The invention also concerns pearls obtained by said method. The method involves feeding into a prilling tower feed container an active ingredient with an undefined melting point and a crystallization excipient, passing the mixture through a vibrating nozzle to form pearls which then fall into the tower countercurrent to the cold air, providing at the base of the tower a fluidized bed whose temperature is held above the glass transition temperature of the active ingredient with an undefined melting point and below the temperature of the start of liquefaction of the excipient.
(FR)
La présente invention concerne un nouveau procédé de préparation de perles d'un composé présentant un point de cristallisation non défini présentant un profil de libération rapide et/ou prolongée. Elle concerne également les perles obtenues par le procédé. Le procédé consiste à introduire dans un récipient d'alimentation d'une tour de 'prilling' le principe actif présentant un point de fusion non défini et un excipient de cristallisation, à passer le mélange à travers une buse vibrée pour former les perles que l'on laisse tomber dans la tour à contre courant avec de l'air froid, à adjoindre en bas de la tour un lit fluidisé dont la température est maintenue en dessus de la température de transition vitreuse du principe actif présentant un point de fusion non défini et en dessous de la température du début de liquéfaction de l'excipient.
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