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1. WO1995032957 - NOVEL ETHOXYCARBONYLOXYMETHYL DERIVATIVES OF SUBSTITUTED BENZIMIDAZOLES

Publication Number WO/1995/032957
Publication Date 07.12.1995
International Application No. PCT/SE1994/000512
International Filing Date 27.05.1994
IPC
C07D 401/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
C07D 401/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
401Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • ASTRA AKTIEBOLAG [SE]/[SE] (AllExceptUS)
  • VON UNGE, Sverker [SE]/[SE] (UsOnly)
Inventors
  • VON UNGE, Sverker
Agents
  • LARSSON, Birgitta
Priority Data
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) NOVEL ETHOXYCARBONYLOXYMETHYL DERIVATIVES OF SUBSTITUTED BENZIMIDAZOLES
(FR) NOUVEAUX DERIVES ETHOXYCARBONYLOXYMETHYLES DE BENZINIDAZOLES SUBSTITUEES
Abstract
(EN)
The novel optically pure compounds, i.e. the single enantiomeric compounds, (-)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H)-benzimidazole-1-ylmethyl ethyl carbonate, (-)-6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-1-ylmethyl ethyl carbonate, (+)-5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-1-ylmethyl ethyl carbonate and (+)-6-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)methyl]sulfinyl]-1H-benzimidazole-1-ylmethyl ethyl carbonate, processes for the preparation thereof and pharmaceutical preparations containing the compounds as active ingredients, as well as the use of the compounds in pharmaceutical preparations and intermediates obtained by preparing the compounds.
(FR)
L'invention porte sur de nouveaux composés optiquement purs, c'est-à-dire sur les composés énantiomères individuels (-)-5-méthoxy-2-[[(4-méthoxy-3,5-diméthyl-2-pyridinyl)méthyl]sulfinyl]-1H-benzimidazole-1-ylméthyl éthyl carbonate, (-)-6-méthoxy-2-[[(4-méthoxy-3,5-diméthyl-2-pyridinyl)méthyl]sulfinyl]-1H-benzimidazole-1-ylméthyl éthyl carbonate, (+)-5-méthoxy-2-[[(4-méthoxy-3,5-diméthyl-2-pyridinyl)méthyl]sulfinyl]-1H-benzimidazole-1-ylméthyl éthyl carbonate, et (+)-6-méthoxy-2-[[(4-méthoxy-3,5-diméthyl-2-pyridinyl)méthyl]sulfinyl]-1H-benzimidazole-1-ylméthyl éthyl carbonate; et sur leurs procédés d'obtention, sur des préparations pharmaceutiques les utilisant comme principes actifs, sur l'utilisation desdits composés dans des préparations pharmaceutiques, et sur leurs intermédiaires de préparation.
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