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1. WO1995032426 - IMPROVED EVALUATION OF TRANSPLANT ACCEPTANCE

Publication Number WO/1995/032426
Publication Date 30.11.1995
International Application No. PCT/US1995/006040
International Filing Date 11.05.1995
Chapter 2 Demand Filed 15.12.1995
IPC
G01N 33/569 2006.1
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
CPC
G01N 33/56977
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
569for microorganisms, e.g. protozoa, bacteria, viruses
56966Animal cells
56977HLA or MHC typing
Y10S 435/961
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
435Chemistry: molecular biology and microbiology
961including a step of forming, releasing, or exposing the antigen or forming the hapten-immunogenic carrier complex or the antigen per se
Y10S 435/962
YSECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
10TECHNICAL SUBJECTS COVERED BY FORMER USPC
STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
435Chemistry: molecular biology and microbiology
962Prevention or removal of interfering materials or reactants or other treatment to enhance results, e.g. determining or preventing nonspecific binding
Applicants
  • SANGSTAT MEDICAL CORPORATION [US]/[US]
Inventors
  • BUELOW, Roland
Agents
  • ROWLAND, Bertram, I.
Priority Data
08/247,99224.05.1994US
Publication Language English (en)
Filing Language English (EN)
Designated States
Title
(EN) IMPROVED EVALUATION OF TRANSPLANT ACCEPTANCE
(FR) EVALUATION AMELIOREE DE L'ACCEPTATION DES GREFFES
Abstract
(EN) Alloantigen is extracted from a cellular source, preferably blood cells, with a mild detergent, and partially purified by precipitation of potentially interfering components. The alloantigen preparation is then used in an assay to determine the presence and specificity of receptors specific for alloantigens. The detection of bound receptor is determined by ELISA or other suitable immunoassays.
(FR) Cette invenetion concerne un alloantigène qu'on a extrait d'une source cellulaire, de préférence de cellules sanguines, avec un détergent doux, et qu'on a partiellement purifié en précipitant les composants susceptibles d'interférer. On utilise ensuite cette préparation d'alloantigène dans un dosage servant à détecter la présence et déterminer la spécificité de récepteurs spécifiques contre les alloantigènes. La détection d'un récepteur lié est déterminée par un dosage ELISA ou par un autre dosage immunologique approprié.
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