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1. WO1995031193 - MATRIX SYSTEM FOR THE TRANSDERMAL DELIVERY OF IBUPROFEN, AND METHOD FOR PREPARING SAME

Publication Number WO/1995/031193
Publication Date 23.11.1995
International Application No. PCT/FR1995/000611
International Filing Date 10.05.1995
Chapter 2 Demand Filed 27.10.1995
IPC
A61K 9/70 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
70Web, sheet or filament bases
A61K 31/19 2006.1
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
19Carboxylic acids, e.g. valproic acid
CPC
A61K 31/19
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31Medicinal preparations containing organic active ingredients
185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
19Carboxylic acids, e.g. valproic acid
A61K 9/7061
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
9Medicinal preparations characterised by special physical form
70Web, sheet or filament bases ; ; Films; Fibres of the matrix type containing drug;
7023Transdermal patches and similar drug-containing composite devices, e.g. cataplasms
703characterised by shape or structure; Details concerning release liner or backing; Refillable patches; User-activated patches
7038Transdermal patches of the drug-in-adhesive type, i.e. comprising drug in the skin-adhesive layer
7046the adhesive comprising macromolecular compounds
7053obtained by reactions only involving carbon to carbon unsaturated bonds, e.g. polyvinyl, polyisobutylene, polystyrene
7061Polyacrylates
A61P 29/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29Non-central analgesic, antipyretic or anti-inflammatory agents, e.g antirheumatic agents; Non-steroidal anti-inflammatory drugs (NSAIDs)
Applicants
  • LABORATOIRES D'HYGIENE ET DE DIETETIQUE [FR]/[FR] (AllExceptUS)
  • SAWAYA, Antoine [FR]/[FR] (UsOnly)
  • MATH, Marie-Christine [FR]/[FR] (UsOnly)
Inventors
  • SAWAYA, Antoine
  • MATH, Marie-Christine
Agents
  • CLISCI, Serge
Priority Data
94/0581811.05.1994FR
Publication Language French (fr)
Filing Language French (FR)
Designated States
Title
(EN) MATRIX SYSTEM FOR THE TRANSDERMAL DELIVERY OF IBUPROFEN, AND METHOD FOR PREPARING SAME
(FR) SYSTEME MATRICIEL POUR ADMINISTRATION TRANSDERMIQUE D'IBUPROFENE ET PROCEDE DE PREPARATION
Abstract
(EN) A self-adhesive transdermal matrix system for the percutaneous delivery of ibuprofen. The matrix system comprises a carrier and a self-adhesive matrix and is characterised in that said matrix includes (a) 55-75 parts by weight of an adhesive acrylate copolymer with a glass transition temperature of -70 to -10 °C, (b) 5-15 parts by weight of a cationic acrylate copolymer with a glass transition temperature of 20-80 °C, (c) 5-15 parts by weight of ibuprofen in free acid form, and (d) 10-25 parts by weight of diethyl phthalate. A method for preparing said matrix system is also disclosed.
(FR) L'invention concerne un système matriciel transdermique auto-adhésif pour l'administration percutanée d'ibuprofène, ledit système matriciel, qui comporte un support et une matrice auto-adhésive, étant caractérisé en ce que ladite matrice comprend: (a) 55 à 75 parties en poids d'un copolymère d'acrylate adhésif ayant une température de transition vitreuse comprise entre -70 et -10 °C, (b) 5 à 15 parties en poids d'un copolymère d'acrylate cationique, présentant une température de transition vitreuse comprise entre 20 et 80 °C, (c) 5 à 15 parties en poids d'ibuprofène sous forme d'acide libre, et (d) 10 à 25 parties en poids de diéthylphtalate. Elle concerne également un procédé de préparation d'un tel système matriciel.
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