WO1995030678 PROCESS FOR THE PREPARATION OF 1-(3-TRIALKYLSILYLPHENYL)-2,2,2-TRIFLUOROMETHYL ETHANONE DERIVATIVES

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Publication Number WO/1995/030678

Publication Date 16.11.1995

International Application No. PCT/US1995/004837

International Filing Date 18.04.1995

Chapter 2 Demand Filed 12.10.1995

IPC

CPC

Applicants

MERRELL DOW PHARMACEUTICALS INC. [US]/[US] (AllExceptUS)
WOLF, Richard, A. [US]/[US] (UsOnly)

Inventors

WOLF, Richard, A.

Agents

LENTZ, Nelsen, L.

Priority Data

08/238,768		05.05.1994		US
08/382,949		01.02.1995		US

Publication Language English (en)

Filing Language English (EN)

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Title

(EN) PROCESS FOR THE PREPARATION OF 1-(3-TRIALKYLSILYLPHENYL)-2,2,2-TRIFLUOROMETHYL ETHANONE DERIVATIVES

(FR) PROCEDE DE PREPARATION DE DERIVES DE 1-(3-TRIALKYLSILYLPHENYL)-2,2,2-TRIFLUOROMETHYLETHANONE

Abstract

(EN) The present invention relates to a novel process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanones which are useful for the treatment of Alzheimer's disease and senile dementia as disclosed by Schirlin, et al. in European Patent Application Publication No. 0 409 676, published January 23, 1991.

(FR) La présente invention concerne un nouveau procédé de préparation de 1-(3-trialkylsilylphényl)-2,2,2-trifluorométhyléthanones qui sont utiles pour le traitement de la maladie d'Alzheimer et de la démence sénile, comme cela avait été décrit dans la demande de brevet européen N° 0 409 676 déposée par Schirlin et publiée le 23 janvier 1991.

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7	Compounds containing elements of Groups 4 or 14 of the Periodic System
02	Silicon compounds
08	Compounds having one or more C-Si linkages

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC, OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7	Compounds containing elements of Groups 4 or 14 of the Periodic System
02	Silicon compounds
08	Compounds having one or more C-Si linkages

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7	Compounds containing elements of Groups 4 or 14 of the Periodic System
02	Silicon compounds
08	Compounds having one or more C—Si linkages
0803	Compounds with Si-C or Si-Si linkages
0825	Preparations of compounds not comprising Si-Si or Si-cyano linkages
083	Syntheses without formation of a Si-C bond

C	CHEMISTRY; METALLURGY
07	ORGANIC CHEMISTRY
F	ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
7	Compounds containing elements of Groups 4 or 14 of the Periodic System
02	Silicon compounds
08	Compounds having one or more C—Si linkages
0803	Compounds with Si-C or Si-Si linkages
0825	Preparations of compounds not comprising Si-Si or Si-cyano linkages
083	Syntheses without formation of a Si-C bond

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1. WO1995030678 - PROCESS FOR THE PREPARATION OF 1-(3-TRIALKYLSILYLPHENYL)-2,2,2-TRIFLUOROMETHYL ETHANONE DERIVATIVES