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1. WO1995024216 - PREVENTION OF DIABETES

Publication Number WO/1995/024216
Publication Date 14.09.1995
International Application No. PCT/NZ1995/000025
International Filing Date 06.03.1995
Chapter 2 Demand Filed 10.05.1995
IPC
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
16
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
17
from animals; from humans
22
Hormones
28
Insulins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
39
characterised by the immunostimulating additives, e.g. chemical adjuvants
A61K 38/28 (2006.01)
A61K 39/00 (2006.01)
A61K 39/39 (2006.01)
CPC
A61K 2039/55544
A61K 2039/55594
A61K 38/28
A61K 39/0008
A61K 39/39
Applicants
  • AUCKLAND UNISERVICES LIMITED [NZ/NZ]; UniServices House 58 Symonds Street Auckland 1001, NZ (AllExceptUS)
  • ELLIOTT, Robert, Bartlett [AU/NZ]; NZ (UsOnly)
Inventors
  • ELLIOTT, Robert, Bartlett; NZ
Agents
  • PIPER, James, William ; James W Piper & Co 46 Brown Street Ponsonby Auckland 1002, NZ
Priority Data
26004607.03.1994NZ
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) PREVENTION OF DIABETES
(FR) PREVENTION DU DIABETE
Abstract
(EN)
The incidence of the autoimmune disease, diabetes mellitus, is well controlled in the nude-obese-diabetic (NOD) mouse model using injections of the A chain fragment (or parts thereof) of the insulin molecule as an antigen in combination with killed cells (or parts thereof) of $i(Haemophilus pertussis), acting as an adjuvant. This leads to the convenient prevention of diabetes in humans using the common 'Triple vaccine' (DPT) diphtheria/whooping cough/tetanus vaccine (or versions thereof) in combination with the A chain fragment of insulin. This mixture can be given to an at-risk population in which diabetes is expected to occur at an abnormally high rate, or it can be given to the entire population.
(FR)
On maîtrise bien l'incidence du diabète sucré, maladie autoimmune, chez la souris nude obèse et diabétique en utilisant des injections de fragment de chaîne A (ou des parties de tels fragments) de molécule d'insuline comme antigène en combinaison avec des cellules tuées (ou des parties de celles-ci) de $i(Haemophilus pertussis), comme adjuvant. Cette procédure constitue un moyen de prévention commode du diabète chez l'être humain, en utilisant le vaccin courant 'triple' (DPT) (diphthérie/coqueluche/tétanos) en combinaison avec un fragment de chaîne A d'insuline. Cette combinaison peut être administrée à une population à haut risque, pour laquelle on peut prévoir une incidence anormale du diabète, ou bien être administrée à l'ensemble de la population.
Also published as
Latest bibliographic data on file with the International Bureau