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1. (WO1995023805) PROCESS FOR PREPARING [L]- OR [D]-HOMOALANIN-4-YL-(METHYL)PHOSPHINIC ACID AND ITS SALTS BY RACEMIC RESOLUTION

Pub. No.:    WO/1995/023805    International Application No.:    PCT/EP1995/000682
Publication Date: Sat Sep 09 01:59:59 CEST 1995 International Filing Date: Sat Feb 25 00:59:59 CET 1995
IPC: C07C 227/36
C07F 9/30
Applicants: HOECHST SCHERING AGREVO GMBH
Inventors: KNORR, Harald
SCHLEGEL, Günter
STARK, Herbert
Title: PROCESS FOR PREPARING [L]- OR [D]-HOMOALANIN-4-YL-(METHYL)PHOSPHINIC ACID AND ITS SALTS BY RACEMIC RESOLUTION
Abstract:
The title compounds are obtained by racemic resolution of D, L-homoalanin-4-yl-(methyl)phosphinic acid by precipitating out one of the diastereomeric salts with chiral bases such as quinine or cinchonine. The yield of desired enantiomers can be increased by transformed racemic resolution, the diastereomeric salt being precipitated when the undesired enantiomer is racemised in the presence of (hetero)aromatic aldehydes. The racemisation method is also suitable for optically active amino acids having other structures.