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1. (WO1995011984) RECOMBINANT ADENOVIRAL VECTOR AND METHODS OF USE
Latest bibliographic data on file with the International Bureau   

Pub. No.: WO/1995/011984 International Application No.: PCT/US1994/012235
Publication Date: 04.05.1995 International Filing Date: 25.10.1994
Chapter 2 Demand Filed: 23.05.1995
IPC:
A61K 38/00 (2006.01) ,C07K 14/47 (2006.01) ,C12N 15/861 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
47
from mammals
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
861
Adenoviral vectors
Applicants:
CANJI, INC. [US/US]; Suite 302 9030 Science Park Road San Diego, CA 92121, US
Inventors:
GREGORY, Richard, J.; US
WILLS, Ken, N.; US
MANEVAL, Daniel, C.; US
Agent:
STEINHARDT, Paul, C. ; Campbell and Flores Suite 700 4370 La Jolla Village Drive San Diego, CA 92122, US
VOELKER, Ingeborg; Uexküll & Stolberg Beselerstrasse 4 D-22607 Hamburg, DE
Priority Data:
08/142,66925.10.1993US
08/246,00719.05.1994US
Title (EN) RECOMBINANT ADENOVIRAL VECTOR AND METHODS OF USE
(FR) VECTEUR RECOMBINANT D'ADENOVIRUS ET PROCEDES D'UTILISATION
Abstract:
(EN) This invention provides a recombinant adenovirus expression vector characterized by the partial or total deletion of the adenoviral protein IX DNA and having a gene encoding a foreign protein or a functional fragment or mutant thereof. Transformed host cells and a method of producing recombinant proteins and gene therapy also are included within the scope of this invention. Thus, for example, the adenoviral vector of this invention can contain a foreign gene for the expression of a protein effective in regulating the cell cycle, such as p53, Rb, or mitosin, or in inducing cell death, such as the conditional suicide gene thymidine kinase. (The latter must be used in conjunction with a thymidine kinase metabolite in order to be effective).
(FR) L'invention concerne un vecteur recombinant d'expression d'adénovirus caractérisé par la suppression totale ou partielle de l'ADN IX de la protéine d'adénovirus et possédant un gène codant une protéine étrangère ou un de ses fragements fonctionnels ou un de ses mutants. L'invention concerne également des cellules hôtes transformées, un procédé d'obtention de protéines recombinantes et de thérapie génétique. De ce fait, par exemple, le vecteur d'adénovirus peut contenir un gène étranger servant à l'expression d'une protéine présentant une efficacité de régulation du cycle cellulaire, telle que p53, Rb ou mitosine, ou de provocation de la mort cellulaire, telle que la thymidine kinase du gène de suicide conditionnel. (Cette dernière doit s'utiliser en combinaison avec un métabolite de thymidine kinase, afin d'être efficace).
Designated States: AM, AU, BB, BG, BR, BY, CA, CN, CZ, FI, GE, HU, JP, KE, KG, KP, KR, KZ, LK, LT, LV, MD, MG, MN, MW, NO, NZ, PL, RO, RU, SD, SI, SK, TJ, TT, UA, UZ, VN
African Regional Intellectual Property Organization (ARIPO) (KE, MW, SD, SZ)
European Patent Office (EPO) (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)