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Pub. No.:    WO/1995/007920    International Application No.:    PCT/US1994/010539
Publication Date: 23.03.1995 International Filing Date: 16.09.1994
Chapter 2 Demand Filed:    17.03.1995    
C07F 9/6512 (2006.01), C07F 9/6561 (2006.01), C07F 9/6571 (2006.01), C07F 9/6574 (2006.01), C07F 9/6578 (2006.01), C07H 19/10 (2006.01), C07H 19/20 (2006.01)
Applicants: GILEAD SCIENCES, INC. [US/US]; 353 Lakeside Drive, Foster City, CA 94404 (US) (For All Designated States Except US).
BISCHOFBERGER, Norbert, W. [AT/US]; (US) (For US Only).
JONES, Robert, J. [US/US]; (US) (For US Only).
ARIMILLI, Murty, N. [IN/US]; (US) (For US Only).
LIN, Kuei-Ying [US/US]; (US) (For US Only).
LOUIE, Michael, S. [US/US]; (US) (For US Only).
MCGEE, Lawwrence, R. [US/US]; (US) (For US Only).
PRISBE, Ernest, J. [US/US]; (US) (For US Only).
LEE, William, A. [US/US]; (US) (For US Only).
CUNDY, Kenneth, C. [US/US]; (US) (For US Only)
Inventors: BISCHOFBERGER, Norbert, W.; (US).
JONES, Robert, J.; (US).
ARIMILLI, Murty, N.; (US).
LIN, Kuei-Ying; (US).
LOUIE, Michael, S.; (US).
MCGEE, Lawwrence, R.; (US).
PRISBE, Ernest, J.; (US).
LEE, William, A.; (US).
CUNDY, Kenneth, C.; (US)
Agent: MUENCHAU, Daryl, D.; Gilead Sciences, Inc., 353 Lakeside Drive, Foster City, CA 94404 (US)
Priority Data:
08/123,483 17.09.1993 US
08/193,341 08.02.1994 US
Abstract: front page image
(EN)Nucleotide analogs characterized by the presence of an amidate linked amino acid or an ester linked group which is bonded to the phosphorus atom of phosphonate nucleotide analogs are disclosed. The analogs comprise a phosphoamidate or ester bond that is hydrolysed $i(in vivo) to yield a corresponding phosphonate nucleotide analog. Methods and intermediates for the synthesis and use are described.
(FR)Analogues de nucléotides caractérisés par la présence d'un acide aminé lié à un amidate ou d'un groupe lié à un ester, qui est lié à l'atome de phosphore d'analogues de nucléotides phosphoniques. Les analogues comprennent une liaison phosphoamidate ou ester qui est hydrolysée $i(in vivo) pour produire un analogue de nucléotide phosphonique correspondant. Des procédés et des intermédiaires permettant la synthèse et l'utilisation de ces analogues sont également décrits.
Designated States: AM, AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, ES, FI, GB, GE, HU, JP, KE, KG, KP, KR, KZ, LK, LT, LU, LV, MD, MG, MN, MW, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SI, SK, TJ, TT, UA, US, UZ, VN.
African Regional Intellectual Property Organization (KE, MW, SD)
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)