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1. WO1994029722 - TWO-PHASE OPTICAL ASSAY METHOD AND APPARATUS

Publication Number WO/1994/029722
Publication Date 22.12.1994
International Application No. PCT/US1994/006427
International Filing Date 08.06.1994
Chapter 2 Demand Filed 06.01.1995
IPC
G01N 33/543 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
G01N 33/58 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58involving labelled substances
G01N 33/72 2006.01
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48Biological material, e.g. blood, urine; Haemocytometers
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
72involving blood pigments, e.g. hemoglobin, bilirubin
CPC
G01N 33/54313
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53Immunoassay; Biospecific binding assay; Materials therefor
543with an insoluble carrier for immobilising immunochemicals
54313the carrier being characterised by its particulate form
G01N 33/582
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
58involving labelled substances
582with fluorescent label
G01N 33/721
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
72involving blood pigments, e.g. haemoglobin, bilirubin ; or other porphyrins; involving occult blood
721Haemoglobin
G01N 33/723
GPHYSICS
01MEASURING; TESTING
NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
48Biological material, e.g. blood, urine
50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
72involving blood pigments, e.g. haemoglobin, bilirubin ; or other porphyrins; involving occult blood
721Haemoglobin
723Glycosylated haemoglobin
Applicants
  • CHRONOMED, INC. [US]/[US]
Inventors
  • SAUNDERS, Alexander
  • ZAROWITZ, Michael, Allan
Agents
  • COOPER, Iver, P.
Priority Data
08/073,45008.06.1993US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) TWO-PHASE OPTICAL ASSAY METHOD AND APPARATUS
(FR) APPAREIL ET PROCEDE DE DOSAGE OPTIQUE EN DEUX PHASES
Abstract
(EN)
A method is provided for measuring an analyte in sample comprising adding substantially transparent particles to a sample in solution or suspension, said particles having an affinity for said analyte; fractionating the particles from the solution or suspension to form a particle-rich fraction and a substantially particle-free fraction; optically reading the particle-rich fraction at a first wavelength; optically reading the substantially particle-free fraction at a second wavelength; and correlating the readings through the particle-rich fraction and the substantially particle-free fraction to obtain a quantitative determination of the analyte originally present in the sample.
(FR)
L'invention concerne un procédé servant à mesurer un analyte dans un échantillon et consistant à ajouter des particules sensiblement transparentes à un échantillon dans une solution ou une suspension, ces particules ayant une affinité pour cet analyte; à fractionner les particules de la solution ou de la suspension pour obtenir une fraction riche en particules et une fraction pratiquement exempte de particules; à lire optiquement la fraction riche en particules à une première longueur d'ondes; à lire optiquement la fraction pratiquement exempte de particules à une seconde longueur d'ondes; et à mettre en corrélation les lectures dans la fraction riche en particules et la fraction pratiquement exempte de particules afin d'obtenir une détermination quantitative de l'analyte présent à l'origine dans l'échantillon.
Also published as
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