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1. WO1994029451 - HUMANISED ANTIBODIES

Publication Number WO/1994/029451
Publication Date 22.12.1994
International Application No. PCT/GB1994/001291
International Filing Date 15.06.1994
Chapter 2 Demand Filed 13.01.1995
IPC
A61K 38/00 2006.01
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
C07K 16/00 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
C07K 16/28 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins, e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
CPC
A61K 38/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38Medicinal preparations containing peptides
A61P 37/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37Drugs for immunological or allergic disorders
C07K 16/00
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
C07K 16/2833
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
16Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
18against material from animals or humans
28against receptors, cell surface antigens or cell surface determinants
2803against the immunoglobulin superfamily
2833against MHC-molecules, e.g. HLA-molecules
C07K 2317/732
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
732Antibody-dependent cellular cytotoxicity [ADCC]
C07K 2317/734
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
KPEPTIDES
2317Immunoglobulins specific features
70characterized by effect upon binding to a cell or to an antigen
73Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
734Complement-dependent cytotoxicity [CDC]
Applicants
  • CELLTECH LIMITED [GB]/[GB] (AllExceptUS)
  • MORGAN, Susan, Adrienne [GB]/[GB] (UsOnly)
  • EMTAGE, John, Spencer [GB]/[GB] (UsOnly)
  • BODMER, Mark, William [GB]/[GB] (UsOnly)
  • ATHWAL, Diljeet, Singh [GB]/[GB] (UsOnly)
Inventors
  • MORGAN, Susan, Adrienne
  • EMTAGE, John, Spencer
  • BODMER, Mark, William
  • ATHWAL, Diljeet, Singh
Agents
  • MERCER, Christopher, Paul
Priority Data
9312415.416.06.1993GB
9401597.127.01.1994GB
9402499.909.02.1994GB
9406222.129.03.1994GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) HUMANISED ANTIBODIES
(FR) ANTICORPS HUMANISES
Abstract
(EN)
The invention describes humanised antibodies having specificity for the epitope recognised by the murine monoclonal antibody L243. Also described are processes for preparing said antibodies and pharmaceutical compositions and medical uses of said antibodies.
(FR)
L'invention concerne des anticorps humanisés possédant une spécificité pour le déterminant antigénique reconnu par l'anticorps monoclonal L243 de murine. Elle concerne également des procédés de préparation desdits anticorps et de compositions pharmaceutiques, ainsi que l'utilisation desdits anticorps en médecine.
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