Search International and National Patent Collections

1. (WO1994029449) HUMAN METABOTROPIC GLUTAMATE RECEPTORS, NUCLEIC ACIDS ENCODING SAME AND USES THEREOF

Pub. No.:    WO/1994/029449    International Application No.:    PCT/US1994/006273
Publication Date: Dec 22, 1994 International Filing Date: Jun 3, 1994
IPC: C07K 14/705
G01N 33/50
Applicants: THE SALK INSTITUTE BIOTECHNOLOGY/INDUSTRIAL ASSOCIATES, INC.
DAGGETT, Lorrie
ELLIS, Steven, B.
LIAW, Chen
PONTSLER, Aaron
JOHNSON, Edwin, C.
HESS, Stephen, D.
Inventors: DAGGETT, Lorrie
ELLIS, Steven, B.
LIAW, Chen
PONTSLER, Aaron
JOHNSON, Edwin, C.
HESS, Stephen, D.
Title: HUMAN METABOTROPIC GLUTAMATE RECEPTORS, NUCLEIC ACIDS ENCODING SAME AND USES THEREOF
Abstract:
In accordance with the present invention, there are provided nucleic acids encoding human metabotropic glutamate receptor subtypes and the proteins encoded thereby. In a particular embodiment, the invention nucleic acids encode mGluR1, mGluR2, mGluR3 and mGluR5 subtypes of human metabotropic glutamate receptors. In addition to being useful for the production of metabotropic glutamate receptor subtypes, these nucleic acids are also useful as probes, thus enabling those skilled in the art, without undue experimentation, to identify and isolate related human receptor subunits. In addition to disclosing novel metabotropic glutamate receptor subtypes, the present invention also comprises methods for using such receptor subtypes to identify and characterize compounds which affect the function of such receptors, e.g., agonists, antagonists, and modulators of glutamate receptor function.