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1. (WO1994029299) IMIDAZOLE LIPOXYGENASE INHIBITORS

Pub. No.:    WO/1994/029299    International Application No.:    PCT/JP1994/000836
Publication Date: Dec 22, 1994 International Filing Date: May 25, 1994
IPC: C07D 233/54
C07D 405/12
C07D 405/14
C07D 521/00
Applicants: PFIZER INC.
PFIZER PHARMACEUTICALS INC.
STEVENS, Rodney, W.
MANO, Takashi
ANDO, Kazuo
Inventors: STEVENS, Rodney, W.
MANO, Takashi
ANDO, Kazuo
Title: IMIDAZOLE LIPOXYGENASE INHIBITORS
Abstract:
Certain novel imidazole derivatives having the ability to inhibit the lipoxygenase enzyme and having formula (I), wherein Y is hydrogen, C1-C8 alkyl, halosubstituted C1-C4 alkyl, phenyl, substituted phenyl, C7-C14 phenylalkyl, C7-C14 (substituted phenyl)alkyl, pyridyl, substituted pyridyl, C6-C13 pyridylalkyl or C6-C13 (substituted pyridyl)alkyl, wherein each substituent is independently halo, nitro, cyano, C1-C4 alkyl, C1-C4 alkoxy, halosubstituted C1-C4 alkyl, halosubstituted C1-C4 alkoxy, NR4R5, CO2R4 or CONR4R5, wherein R?4 and R5¿ are each, independently, hydrogen or C¿1?-C6 alkyl; Ar?1 and Ar2¿ are each, independently, phenylene, mono-substituted phenylene or di-substituted phenylene, wherein the substituents are, independently, halo, C¿1?-C4 alkyl, C1-C4 alkoxy, halo-substituted C1-C4 alkyl or halo-substituted C1-C4 alkoxy; X and X?1¿ are each, independently, O, S, SO or SO¿2; R?1 is hydrogen or C¿1?-C4 alkyl; and R?2 and R3¿ are each, independently, methylene, ethylene or propylene. These compounds are useful for the treatment of disease states such as bronchial asthma, skin disorders and arthritis in mammals, and as the active ingredient in pharmaceutical compositions for treating such conditions.