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1. WO1994029298 - 8-AMINO-7-CHLORO-1,4-BENZODIOXAN-5-CARBOXYLIC ACID, -1-BUTYL-4-PIPERIDINYL ESTER AS A 5-HT4-RECEPTOR ANTAGONIST

Publication Number WO/1994/029298
Publication Date 22.12.1994
International Application No. PCT/EP1994/001939
International Filing Date 14.06.1994
Chapter 2 Demand Filed 10.01.1995
IPC
C07D 405/12 2006.01
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
CPC
A61P 1/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1Drugs for disorders of the alimentary tract or the digestive system
A61P 25/00
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25Drugs for disorders of the nervous system
A61P 9/08
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
08Vasodilators for multiple indications
A61P 9/10
AHUMAN NECESSITIES
61MEDICAL OR VETERINARY SCIENCE; HYGIENE
PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9Drugs for disorders of the cardiovascular system
10for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
C07D 405/12
CCHEMISTRY; METALLURGY
07ORGANIC CHEMISTRY
DHETEROCYCLIC COMPOUNDS
405Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
02containing two hetero rings
12linked by a chain containing hetero atoms as chain links
Applicants
  • SMITHKLINE BEECHAM PLC [GB]/[GB] (AllExceptUS)
  • GASTER, Laramie, Mary [GB]/[GB] (UsOnly)
Inventors
  • GASTER, Laramie, Mary
Agents
  • JONES, Pauline
  • GIDDINGS, Peter, John
Priority Data
9312348.716.06.1993GB
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) 8-AMINO-7-CHLORO-1,4-BENZODIOXAN-5-CARBOXYLIC ACID, -1-BUTYL-4-PIPERIDINYL ESTER AS A 5-HT4-RECEPTOR ANTAGONIST
(FR) ACIDE 8-AMINO-7-CHLORO-1,4-BENZODIOXANE-5-CARBOXYLIQUE, ESTER DE -1-BUTYL-4-PIPERIDINYLE UTILISE EN TANT QU'ANTAGONISTE DU RECEPTEUR DE 5-HT4
Abstract
(EN)
The preparation of 8-amino-7-chloro-1, 4-benzodioxan-5-(1-butyl-4-piperidinyl)carboxylate of formula (I) for use as a 5-HT4 receptor antagonist in the treatment or prophylaxis of gastrointestinal disorders, cardiovascular disorders and CNS disorders.
(FR)
L'invention concerne la préparation de 8-amino-7-chloro-1,4-benzodioxane-5(1-butyl-4-piperidinyl)carboxylate de formule (I) destiné à être utilisé en tant qu'antagoniste du récepteur de 5-HT4 dans le traitement ou la prophylaxie de troubles gastro-intestinaux, vasculaires et du SNC.
Also published as
Latest bibliographic data on file with the International Bureau