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1. (WO1994029293) NOVEL 8-(2-AMINOALKOXY)FLUOROCHROMAN DERIVATIVE

Pub. No.:    WO/1994/029293    International Application No.:    PCT/JP1994/000923
Publication Date: Dec 22, 1994 International Filing Date: Jun 8, 1994
IPC: C07D 311/22
C07D 407/12
Applicants: YAMANOUCHI PHARMACEUTICAL CO., LTD.

YASUNAGA, Tomoyuki

KIMURA, Takenori

NAITO, Ryo

KONTANI, Toru

YAMAGUCHI, Tokio

WANIBUCHI, Fumikazu

Inventors: YASUNAGA, Tomoyuki

KIMURA, Takenori

NAITO, Ryo

KONTANI, Toru

YAMAGUCHI, Tokio

WANIBUCHI, Fumikazu

Title: NOVEL 8-(2-AMINOALKOXY)FLUOROCHROMAN DERIVATIVE
Abstract:
An 8-(2-aminoalkoxy)fluorochroman derivative represented by general formula (I) or a salt thereof, both having a selective affinity for 5-HT1A receptors and being useful for treating psychoneurotic diseases such as anxiety, manic-depressive state and schizophrenia, sex disorder, eating disorder, sleep disorder, and drug dependence: wherein R1, R2 and R3 represent each lower alkoxy, etc., or R1 and R2 may be combined together to represent -O-(CH2)m-O- (wherein m is an integer of 1 to 3), etc.; R4 represents hydrogen, lower alkyl or aralkyl; R5 represent hydroxy, amino or lower alkoxy; R6 represents hydrogen or lower alkyl, provided R5, R6 and the carbon atom to which they are bonded are combined together to represent carbonyl; A represents an ethylene group which may be substituted by lower alkyl; and B represents optionally branched C1-C10 alkylene.