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1. (WO1994028950) PLASMA-LIKE SOLUTION

Pub. No.:    WO/1994/028950    International Application No.:    PCT/US1994/006279
Publication Date: Dec 22, 1994 International Filing Date: Jun 3, 1994
IPC: A01N 1/02
A61K 33/10
A61K 33/14
Applicants: BIOTIME, INC.
Inventors: SEGALL, Paul, E.
STERNBERG, Hal
WAITZ, Harold, D.
SEGALL, Judith, M.
Title: PLASMA-LIKE SOLUTION
Abstract:
Aqueous solutions comprising a polysaccharide oncotic agent, a physiologically compatible buffer, a simple hexose sugar, dissolved chloride salts of calcium, sodium and magnesium, and a dissolved organic salt of sodium are disclosed. The solutions are effective substitutes for blood and may be used to preserve the biological integrity of the organs of a mammalian donor organism as shown by superior anatomical integrity of cryopreserved organs and tissues of subjects perfused with the solution. The solutions may be used for maintaining a partially or substantially completely exsanguinated subject at normal temperatures and at temperatures substantially below those normally maintained by a mammal and may be used in conjunction with hypobaric environments to maintain such partially or completed exsanguinated subjects alive without infusing blood back into the subject.