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1. (WO1994028726) METHOD OF TREATING RETAINED PULMONARY SECRETIONS

Pub. No.:    WO/1994/028726    International Application No.:    PCT/US1994/006486
Publication Date: Dec 22, 1994 International Filing Date: Jun 8, 1994
IPC: A61K 38/04
A61K 38/12
A61K 38/16
Applicants: THE WELLCOME FOUNDATION LIMITED
THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL
MOLINA y VEDIA, Luis, M.
STUTTS, Monroe, Jackson
BOUCHER, Richard, C., Jr.
HENKE, David, C.
Inventors: MOLINA y VEDIA, Luis, M.
STUTTS, Monroe, Jackson
BOUCHER, Richard, C., Jr.
HENKE, David, C.
Title: METHOD OF TREATING RETAINED PULMONARY SECRETIONS
Abstract:
A method of facilitating the clearance of retained pulmonary secretions in a subject using lantibiotics is disclosed. The method comprises administering to the lungs of the subject an effective amount of a lantibiotic. The lantibiotic is preferably administered by topically applying it to the respiratory epithelia, such as by generating an aerosol thereof which is then inhaled by the subject. A preferred lantibiotic for carrying out the present invention is duramycin. The method may be used in treating disorders such as cystic fibrosis, chronic bronchitis, and asthma. Also disclosed is a method of combatting tuberculosis comprising administering a lantibiotic to a subject in need of such treatment.