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1. (WO1994027994) PIPERIDINE DERIVATIVES, THEIR PREPARATION AND USE

Pub. No.:    WO/1994/027994    International Application No.:    PCT/DK1994/000197
Publication Date: Dec 8, 1994 International Filing Date: May 19, 1994
IPC: C07D 401/04
C07D 401/14
C07D 405/14
C07D 413/04
C07D 413/14
C07D 417/14
C07D 491/04
Applicants: NOVO NORDISK A/S
Inventors: HANSEN, John, Bondo
GRØNVALD, Frederik, Christian
MOGENSEN, John, Patrick
Title: PIPERIDINE DERIVATIVES, THEIR PREPARATION AND USE
Abstract:
Piperidine derivatives of formula (I) wherein A is straight or branched alkyl, alkoxy-alkyl, or alkenyl; X is O or NH; Y is O, S, NH, NCN, or N-alkyl; R1 is 6-fluoro-1,2-benzisoxazol-3-yl, 6-fluoro-1H-indazol-3-yl, or 6-fluoro-1-methyl-1H-indazol-3-yl; R2 is alkyl or phenyl; and R3 is phenyl optionally substituted, or R3 is (a) wherein Z represents a 5- or 6-membered heterocyclic ring; or R?2 and R3¿ together with the nitrogen atom form a fused heterocyclic ring system; or pharmaceutically acceptable salts thereof are useful in the treatment of indications related to the CNS-system, cardiovascular system or to gastrointestinal disorders.