WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO1994027964) 3-(INDOL-3-YL) PROPENOIC ACID DERIVATIVES AND AS NMDA ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/027964    International Application No.:    PCT/US1994/005023
Publication Date: 08.12.1994 International Filing Date: 02.05.1994
Chapter 2 Demand Filed:    15.11.1994    
IPC:
C07D 209/42 (2006.01), C07F 7/10 (2006.01)
Applicants: MERRELL DOW PHARMACEUTICALS INC. [US/US]; 2110 East Galbraith Road, P.O. Box 156300, Cincinnati, OH 45215-6300 (US) (For All Designated States Except US).
SALITURO, Francesco, G. [US/US]; (US) (For US Only).
BARON, Bruce, M. [US/US]; (US) (For US Only).
HARRISON, Boyd, L. [US/US]; (US) (For US Only)
Inventors: SALITURO, Francesco, G.; (US).
BARON, Bruce, M.; (US).
HARRISON, Boyd, L.; (US)
Agent: SAYLES, Michael, J.; Marion Merrell Dow Inc., 2110 East Galbraith Road, P.O. Box 156300, Cincinnati, OH 45215-6300 (US)
Priority Data:
08/068,367 27.05.1993 US
08/139,323 19.10.1993 US
08/190,814 02.02.1994 US
Title (EN) 3-(INDOL-3-YL) PROPENOIC ACID DERIVATIVES AND AS NMDA ANTAGONISTS
(FR) DERIVES D'ACIDE 3-(INDOL-3-YL) PROPENOÏQUE ET ANTAGONISTES DE NMDA
Abstract: front page image
(EN)A compound of formula (I), wherein Z is hydrogen, -CH¿3?, or -C¿2?H¿5?; X and Y are represented by -OH, a physiologically acceptable ester, or a physiologically acceptable amide; R is represented by from 1 to 3 substituents independently chosen from the group: hydrogen, C¿1-4? alkyl, C¿1-4? alkoxy, halogen, -CF¿3?, or -OCF¿3?; R¿1? is represented by from 1 to 3 substituents independently chosen from the group: hydrogen, amino, C¿1-4? alkyl, C¿1-4? alkoxy, halogen, -CF¿3?, or -OCF¿3?; and pharmaceutically acceptable addition salts thereof. These 3-indolyl-3-yl-propenoic acid derivatives are useful as NMDA antagonist.
(FR)L'invention concerne un composé de la formule (I) dans laquelle Z représente hydrogène, -CH¿3?, ou -C¿2?H¿5?; X et Y sont représentés par -OH, un ester ou un amide physiologiquement acceptable, R est réprésenté par 1 à 3 substituants choisis indépendamment dans le groupe: hydrogène, alkyle C¿1-4?, alcoxy C¿1-4?, halogène, -CF¿3?, ou -OCF¿3?; R¿1? est représenté par 1 à 3 substituants choisis indépendamment dans le groupe: hydrogène, amino, alkyle C¿1-4?, alcoxy C¿1-4?, halogène, -CF¿3?, ou -OCF¿3?; ainsi que leurs sels d'addition pharmaceutiquement acceptables. Ces dérivés d'acide 3-indolyl-3-yl-propénoïque sont utiles comme antagonistes de NMDA.
Designated States: AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, ES, FI, GB, HU, JP, KP, KR, KZ, LK, LU, LV, MG, MN, MW, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SK, UA, US, UZ, VN.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)