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Machine translation
1. (WO1994027955) INTERMEDIATES AND PROCESS OF MAKING DIPEPTIDE ISOSTERES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/027955    International Application No.:    PCT/US1994/005862
Publication Date: 08.12.1994 International Filing Date: 24.05.1994
Chapter 2 Demand Filed:    28.11.1994    
IPC:
C07C 229/34 (2006.01), C07C 259/06 (2006.01), C07D 307/20 (2006.01), C07D 307/33 (2006.01), C07D 317/26 (2006.01), C07D 319/06 (2006.01)
Applicants: SMITHKLINE BEECHAM CORPORATION [US/US]; Corporate Intellectual Property, UW2220, 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406-0939 (US)
Inventors: RYCKMAN, David, Malcolm; (US)
Agent: SUTER, Stuart, R.; SmithKline Beecham Corporation, Corporate Intellectual Property, UW2220, 709 Swedeland Road, P.O. Box 1539, King of Prussia, PA 19406-0939 (US)
Priority Data:
08/066,959 24.05.1993 US
Title (EN) INTERMEDIATES AND PROCESS OF MAKING DIPEPTIDE ISOSTERES
(FR) INTERMEDIAIRES ET PROCEDE DE PRODUCTION D'ISOSTERES DIPEPTIDIQUES
Abstract: front page image
(EN)Intermediates and a stereoselective process for preparing hydroxyethylene dipeptide isosteres and lactone compounds which process comprises, as an essential step, the stereoselective reduction of the keto group in a 5S-4-keto-5-dibenzylamino-6-phenylhexanal ethylene (or propylene) acetal. The intermediates and process of this invention are useful in the preparation of enzyme inhibitors, which are, in particular, active against the HIV-1 virus.
(FR)L'invention concerne des intermédiaires et un procédé stéréosélectif de préparation d'isostères peptidiques hydroxyéthyléniques et de composés de lactone. Ledit procédé consiste principalement à réduire stéréosélectivement le groupe céto en acétal d'éthylène (ou propylène) de 5S-4-céto-5-dibenzylamino-6-phénylhexanal. Les intermédiaires et le procédé selon l'invention sont utiles dans la préparation d'inhibiteurs enzymatiques qui sont, en particulier, actifs contre le virus VIH-1.
Designated States: JP.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)