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1. (WO1994027952) NOVEL ANTIVIRAL AGENTS

Pub. No.:    WO/1994/027952    International Application No.:    PCT/US1994/005975
Publication Date: Dec 8, 1994 International Filing Date: May 27, 1994
IPC: C07C 69/00
Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD.
NEW YORK UNIVERSITY
Inventors: MAZUR, Yehuda
LAVIE, Gad
MERUELO, Daniel
LAVIE, David
Title: NOVEL ANTIVIRAL AGENTS
Abstract:
Novel antiviral (including antiretroviral) compounds are mono- or dicarboxylic acid esters of hypericin in which one or both of the methyl groups of hypericin are substituted by carboxylic acid ester groups of the formula COOR3 in which R3 is alkyl, the chain of which is optionally interrupted by one or more oxygen or sulphur atoms. R3 is preferably methyl, ethyl, propyl, butyl, 2-methoxyethyl or 2-(2-methoxyethoxy)ethyl. The compounds may be formulated into pharmaceutical compositions and may be used in any manner which has previously been known for hypericin.