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1. (WO1994027641) AMPLIFICATION OF THE VITAMIN B12 UPTAKE SYSTEM USING POLYMERS

Pub. No.:    WO/1994/027641    International Application No.:    PCT/AU1994/000273
Publication Date: Dec 8, 1994 International Filing Date: May 24, 1994
IPC: A61K 38/00
A61K 47/48
C07K 7/02
C07K 7/23
C07K 14/00
Applicants: BIOTECH AUSTRALIA PTY. LIMITED
RUSSELL-JONES, Gregory, John
WESTWOOD, Steven, William
GOULD, Alison, Ruth
McINERNEY, Bernard, Vincent
Inventors: RUSSELL-JONES, Gregory, John
WESTWOOD, Steven, William
GOULD, Alison, Ruth
McINERNEY, Bernard, Vincent
Title: AMPLIFICATION OF THE VITAMIN B12 UPTAKE SYSTEM USING POLYMERS
Abstract:
The invention relates to the oral delivery of peptide and protein pharmaceuticals using the vitamin B12 (VB12) uptake system, with the delivery being amplified using polymers. More particularly, the invention concerns a complex having the general formula: (V - Q)n- P - (Q' - A)m, where V is a carrier which will bind to natural intrinsic factor (IF) selected from vitamin B12 or an analogue thereof, n is the molar substitution ratio of V in the complex, and is a number from 1.0 to about 10, P is a pharmaceutically acceptable polymer, A is a pharmaceutically active substance, m is the molar substitution ratio of A in the complex, and is a number greater than 1.0 to about 1000, Q and Q' are independently a covalent bond, or a spacer compound linking V, P and A by covalent bonds.