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Machine translation
1. (WO1994027601) ALIPHATIC AMINO BIS-ARYL SQUALENE SYNTHASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/027601    International Application No.:    PCT/US1994/005283
Publication Date: 08.12.1994 International Filing Date: 11.05.1994
Chapter 2 Demand Filed:    09.12.1994    
IPC:
C07C 217/22 (2006.01), C07C 233/75 (2006.01), C07C 235/56 (2006.01), C07D 263/57 (2006.01), C07D 413/12 (2006.01)
Applicants: RHONE-POULENC RORER PHARMACEUTICALS INC. [US/US]; 500 Arcola Road, P.O. Box 1200, Mail Stop 3C43, Collegeville, PA 19426-0107 (US) (For All Designated States Except US).
GRONEBERG, Robert, D. [US/US]; (US) (For US Only).
REGAN, John, R. [US/US]; (US) (For US Only).
NEUENSCHWANDER, Kent, W. [US/US]; (US) (For US Only).
SCOTESE, Anthony, C. [US/US]; (US) (For US Only)
Inventors: GRONEBERG, Robert, D.; (US).
REGAN, John, R.; (US).
NEUENSCHWANDER, Kent, W.; (US).
SCOTESE, Anthony, C.; (US)
Agent: NICHOLSON, James, A.; Rhône-Poulenc Rorer Inc., 500 Arcola Road, P.O. Box 1200, Collegeville, PA 19426 (US)
Priority Data:
08/065,966 21.05.1993 US
Title (EN) ALIPHATIC AMINO BIS-ARYL SQUALENE SYNTHASE INHIBITORS
(FR) COMPOSES AMINO BIS-ARYLE ALIPHATIQUES INHIBITEURS DE LA SQUALENE SYNTHETASE
Abstract: front page image
(EN)This invention relates to a class of novel aliphatic amino bis-aryl compounds containing at least four carbon atoms and an amino group either substituted thereon or incorporated therein and is furhter linked or bridged to two mono- and/or bicyclic rings. Compounds of this invention reduce levels of serum cholesterol in the body without significantly reducing mevalonic metabolite synthesis. This invention relates also to pharmacological compositions and method of treatment for lowering serum cholesterol levels using the compounds of this invention.
(FR)Cette invention concerne une classe de nouveaux composés amino bis-aryle aliphatiques contenant au moins quatre atomes de carbone et un groupe amino substituant ou incorporé dans la structure et en outre lié ou formant un pont avec deux groupes mono- et ou bicycliques. Les composés de cette invention réduisent les niveaux du cholestérol du sérum dans le corps sans diminuer d'une manière significative la synthèse du métabolite mévalonique. Cette invention concerne également des compostions pharmacologiques et un procédé de traitement pour diminuer les niveaux de cholestérol du sérum en utilisant les composés de cette invention.
Designated States: AT, AU, BB, BG, BR, BY, CA, CH, CN, CZ, DE, DK, ES, FI, GB, HU, JP, KP, KR, KZ, LK, LU, LV, MG, MN, MW, NL, NO, NZ, PL, PT, RO, RU, SD, SE, SK, UA, US, UZ, VN.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)