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Machine translation
1. (WO1994026771) PROCESS FOR THE STEREOSELECTIVE PREPARATION OF L-ALANYL-L-PROLINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/026771    International Application No.:    PCT/US1994/005553
Publication Date: 24.11.1994 International Filing Date: 18.05.1994
Chapter 2 Demand Filed:    14.12.1994    
IPC:
C07D 207/16 (2006.01), C07K 5/062 (2006.01)
Applicants: CELGENE CORPORATION [US/US]; 7 Powder Horn Drive, Warren, NJ 07059 (US).
BURBAUM, Beverly, W. [US/US]; (US).
LI, Chunshi [CN/US]; (US).
MATCHAM, George, W. [GB/US]; (US)
Inventors: BURBAUM, Beverly, W.; (US).
LI, Chunshi; (US).
MATCHAM, George, W.; (US)
Agent: COLLINS, Bruce, M.; Mathews, Woodbridge & Collins, Suite 306, 100 Thanet Circle, Princeton, NJ 08540 (US).
ALEXANDER, Jane, E.; Mathews, Woodbridge & Collins, P.A., Suite 306, 100 Thanet Circle, Princeton, NJ 08540-3662 (US)
Priority Data:
08/063,434 18.05.1993 US
Title (EN) PROCESS FOR THE STEREOSELECTIVE PREPARATION OF L-ALANYL-L-PROLINE
(FR) PROCEDE DE PREPARATION STEREOSELECTIVE DE L-ALANYL-L-PROLINE
Abstract: front page image
(EN)L-alanyl-L-proline is stereoselectively prepared catalytically hydrogenating an N-(2-iminopropionyl)-L-proline in the presence of a metal hydrogenolysis catalyst and at a pH of less than about 4. Also disclosed are improved processes for production of N-pyruvyl-L-proline in which L-proline and a 2,2-disubstituted propionyl halide are allowed to react at a pH of at least 9 to produce an L-proline intermediate which is hydrolyzed at a pH range of from about 6.5 to about 8.5 to yield N-pyruvyl-L-proline.
(FR)On prépare stéréosélectivement une L-alanyl-L-proline en hydrogénant par voie catalytique une N-(2-iminopropionyl)-L-proline en présence d'un catalyseur d'hydrogénolyse métallique et à un pH inférieur à environ 4. L'invention se rapporte également à des procédés améliorés de production de N-pyruvyl-L-proline, selon lesquels on laisse réagir la L-proline et un halogénure de propionyle bisubstitué en position 2,2 à un pH d'au moins 9, pour produire un intermédiaire de L-proline qui est hydrolysé à un pH compris entre environ 6,5 et environ 8,5 pour produire N-pyruvyl-L-proline.
Designated States: CA, JP.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)