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1. (WO1994026755) BICYCLOPOLYAZAMACROCYCLOPHOSPHONIC ACID COMPLEXES, A PROCESS FOR THEIR PREPARATION, AND THEIR CONJUGATES, FOR USE AS RADIOPHARMACEUTICALS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/026755    International Application No.:    PCT/US1993/004356
Publication Date: 24.11.1994 International Filing Date: 06.05.1993
Chapter 2 Demand Filed:    02.12.1994    
IPC:
A61K 51/04 (2006.01), A61K 51/10 (2006.01), C07F 9/6561 (2006.01)
Applicants: THE DOW CHEMICAL COMPANY [US/US]; 2030 Dow Center, Abbott Road, Midland, MI 48640 (US)
Inventors: KIEFER, Garry, E.; (US).
SIMON, Jaime; (US)
Agent: KIMBLE, Karen, L.; The Dow Chemical Company, Patent Department, P.O. Box 1967, Midland, MI 48641-1967 (US)
Priority Data:
Title (EN) BICYCLOPOLYAZAMACROCYCLOPHOSPHONIC ACID COMPLEXES, A PROCESS FOR THEIR PREPARATION, AND THEIR CONJUGATES, FOR USE AS RADIOPHARMACEUTICALS
(FR) COMPLEXES D'ACIDES BICYCLOPOLYAZAMACROCYCLOPHOSPHONIQUES, CONJUGUES DE CES DERNIERS, PROCEDE DE PREPARATION ASSOCIE ET D'UTILISATION EN TANT QUE PRODUITS RADIOPHARMACEUTIQUES
Abstract: front page image
(EN)Complexes of bicyclopolyazamacrocyclophosphonic acid compounds with a metal ion, e.g. ?153¿Sm, ?177¿Lu, ?159¿Gd, ?149¿Pm, ?140¿La, ?175¿Yb, ?166¿Ho, ?90¿Y, ?47¿Sc, ?186¿Re, ?188¿Re, ?142¿Pr, ?99m¿Tc, ?67¿Ga, ?68¿Ga, ?105¿Rh, ?97¿Ru, ?111¿In, ?113m¿In or ?115m¿In ion, are disclosed. The complexes can be covalently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complexes and conjugates are useful as radiopharmaceutical agents for therapy and/or diagnostic purposes. Processes for preparing the complex and conjugate are discussed.
(FR)Complexes de composés d'acides bicyclopolyazamacrocyclophosphoniques comprenant un ion métal tel que ?153¿Sm, ?177¿Lu, ?159¿Gd, ?149¿Pm, ?140¿La, ?175¿Yb, ?166¿Ho, ?90¿Y, ?47¿Sc, ?186¿Re, ?188¿Re, ?142¿Pr, ?99m¿Tc, ?67¿Ga, ?68¿Ga, ?105¿Rh, ?97¿Ru, ?111¿In, ?113m¿In ou ?115m¿In. Les complexes peuvent être liés par covalence à une molécule biologiquement active telle qu'un anticorps ou un fragment d'anticorps pour former des conjugués. Les complexes et les conjugués sont utiles comme agents radiopharmaceutiques dans des applications de thérapie et/ou de diagnostic. Des procédés de préparation du complexe et du conjugué sont également présentés.
Designated States: AU, BR, CA, FI, HU, JP, KR, RU, UA.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)