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Machine translation
1. (WO1994026315) BICYCLOPOLYAZAMACROCYCLOCARBOXYLIC ACID COMPLEXES, THEIR CONJUGATES, PROCESSES FOR THEIR PREPARATION, AND USE AS RADIOPHARMACEUTICALS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/026315    International Application No.:    PCT/US1993/004311
Publication Date: 24.11.1994 International Filing Date: 06.05.1993
IPC:
A61K 51/04 (2006.01), A61K 51/10 (2006.01)
Applicants: THE DOW CHEMICAL COMPANY [US/US]; 2030 Dow Center, Abbott Road, Midland, MI 48640 (US)
Inventors: KIEFER, Garry, E.; (US).
SIMON, Jaime; (US)
Agent: KIMBLE, Karen, L.; The Dow Chemical Company, Patent Department, P.O. Box 1967, Midland, MI 48641-1967 (US)
Priority Data:
Title (EN) BICYCLOPOLYAZAMACROCYCLOCARBOXYLIC ACID COMPLEXES, THEIR CONJUGATES, PROCESSES FOR THEIR PREPARATION, AND USE AS RADIOPHARMACEUTICALS
(FR) COMPLEXES ET CONJUGUES DE COMPLEXES D'ACIDES BICYCLOPOLYAZAMACROCYCLOCARBOXYLIQUES, PROCEDES DE PREPARATION DE CES DERNIERS ET D'UTILISATION EN TANT QUE PRODUITS RADIOPHARMACEUTIQUES
Abstract: front page image
(EN)Complexes of bicyclopolyazamacrocyclocarboxylic acid compounds with a metal ion, e.g. ?153¿Sm, ?177¿Lu, ?159¿Gd, ?149¿Pm, ?140¿La, ?175¿Yb, ?166¿Ho, ?90¿Y, ?47¿Sc, ?186¿Re, ?188¿Re, ?142¿Pr, ?99m¿Tc, ?67¿Ga, ?68¿Ga, ?105¿Rh, ?97¿Ru, ?111¿In, ?113m¿In or ?115m¿In ion, are disclosed. The complexes can be covalently attached to a biologically active molecule, e.g. an antibody or antibody fragment, to form conjugates. The complexes and conjugates are useful as radiopharmaceutical agents for therapy and/or diagnostic purposes. Processes to prepare the complex and conjugate are discussed.
(FR)Complexes de composés d'acides bicyclopolyazamacrocyclocarboxyliques comprenant un ion métal tel qu'un ion ?153¿Sm, ?177¿Lu, ?159¿Gd, ?149¿Pm, ?140¿La, ?175¿Yb, ?166¿Ho, ?90¿Y, ?47¿Sc, ?186¿Re, ?188¿Re, ?142¿Pr, ?99m¿Tc, ?67¿Ga, ?68¿Ga, ?105¿Rh, ?97¿Ru, ?111¿In, ?113m¿In ou ?115m¿In. Ces complexes peuvent être liés de manière covalente à une molécule biologiquement active telle qu'un anticorps ou un fragment d'anticorps, pour former des conjugués. Les complexes et les conjugués sont utiles comme agents radiopharmaceutiques dans des applications de thérapie et/ou de diagnostic. Des procédés de préparation du complexe et du conjugué sont également décrits.
Designated States: AU, BR, CA, FI, HU, JP, KR, RU, UA.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE).
Publication Language: English (EN)
Filing Language: English (EN)