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1. (WO1994026307) INHIBITION OF MIGRATION INHIBITORY FACTOR IN THE TREATMENT OF DISEASES INVOLVING CYTOKINE-MEDIATED TOXICITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/1994/026307    International Application No.:    PCT/US1994/005433
Publication Date: 24.11.1994 International Filing Date: 16.05.1994
Chapter 2 Demand Filed:    15.12.1994    
IPC:
A61K 48/00 (2006.01), C07K 14/52 (2006.01), C07K 14/575 (2006.01), C07K 14/72 (2006.01), C07K 16/24 (2006.01), C07K 16/26 (2006.01), C12N 15/85 (2006.01)
Applicants: THE PICOWER INSTITUTE FOR MEDICAL RESEARCH [US/US]; 350 Community Drive, Manhasset, NY 11030 (US)
Inventors: BUCALA, Richard, J.; (US).
MITCHELL, Robert, A.; (US).
BERNHAGEN, Jurgen; (US).
CALANDRA, Thierry, F.; (US).
CERAMI, Anthony; (US)
Agent: CORUZZI, Laura, A.; Pennie & Edmonds, 1155 Avenue of the Americas, New York, NY 10036 (US)
Priority Data:
063,399 17.05.1993 US
Title (EN) INHIBITION OF MIGRATION INHIBITORY FACTOR IN THE TREATMENT OF DISEASES INVOLVING CYTOKINE-MEDIATED TOXICITY
(FR) INHIBITION DE LA MIGRATION DU FACTEUR INHIBITEUR DANS LE TRAITEMENT DE MALADIES IMPLIQUANT UNE TOXICITE TRANSMISE PAR LA CYTOKINE
Abstract: front page image
(EN)The present invention relates to compositions and methods for inhibiting the release and/or biological activity of migration inhibitory factor (MIF). In particular, the invention relates to the uses of such compositions and methods for the treatment of various conditions involving cytokine-mediated toxicity, which include, but are not limited to shock, inflammation, graft versus host disease, and/or autoimmune diseases.
(FR)L'invention concerne des compositions et des procédés pour inhiber la libération et/ou l'activité biologique du facteur inhibiteur de migration. L'invention porte, plus particulièrement sur les utilisations desdits procédés et compositions pour le traitement de diverses pathologies impliquant une toxicité transmise par la cytokine telles que le choc, l'inflammation, la réaction du greffon contre l'hôte et/ou les maladies auto-immunes.
Designated States: AU, BB, BG, BR, BY, CA, CN, CZ, FI, GE, HU, JP, KG, KR, KZ, LK, LV, MD, MG, MN, MW, NO, NZ, PL, RO, RU, SD, SI, SK, TJ, UA, UZ.
European Patent Office (AT, BE, CH, DE, DK, ES, FR, GB, GR, IE, IT, LU, MC, NL, PT, SE)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)